{"id":"W2257952977","doi":"10.1016/j.pnpbp.2016.01.008","title":"Neuropathological relationship between major depression and dementia: A hypothetical model and review","year":2016,"lang":"en","type":"review","venue":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":105,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research; Mitacs; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Excitotoxicity; Neurodegeneration; Neuroscience; Neurotrophic factors; Neurogenesis; Major depressive disorder; Brain-derived neurotrophic factor; Psychology; Medicine; Glutamate receptor; Internal medicine; Amygdala; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005512538,0.0007389066,0.001595343,0.0002429265,0.0002841016,0.0000521315,0.0004800635,0.0008890526,0.00005100463],"category_scores_gemma":[0.0007058955,0.0004351898,0.0002086636,0.0003896528,0.001677987,0.0001134151,0.0005316343,0.001435532,0.00002109109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001217613,"about_ca_system_score_gemma":0.0000631666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":1.106362e-7,"about_ca_topic_score_gemma":2.787993e-7,"domain_scores_codex":[0.9943883,0.001801138,0.0009974722,0.001934961,0.0001903399,0.0006877652],"domain_scores_gemma":[0.9965383,0.002411888,0.000396784,0.0003069332,0.00001542416,0.0003307035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001671303,0.0003174424,0.2623824,0.006913714,0.00002503322,0.00009740674,0.000006328718,3.12014e-8,0.000007102144,0.00187451,0.0008836137,0.7273253],"study_design_scores_gemma":[0.008900168,0.001577758,0.4299242,0.02709851,0.001610768,0.002032645,0.000005741061,0.00005640529,0.000002243142,0.03729534,0.4883758,0.003120447],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02075648,0.9745636,0.00001847122,0.002112813,0.0004936535,0.001675814,0.00008157592,0.0001291096,0.0001684936],"genre_scores_gemma":[0.02533723,0.9682923,0.000352733,0.005376462,0.0001764312,0.0003963012,0.000009308646,0.00004506325,0.00001418501],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7242048,"threshold_uncertainty_score":0.99981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09650358469682994,"score_gpt":0.38771710112107,"score_spread":0.29121351642424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}