{"id":"W2257954678","doi":"10.1093/nar/gkw050","title":"Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease","year":2016,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ontario Ministry of Economic Development and Innovation; Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Diamond Light Source; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Endoribonuclease; Biology; Mitochondrion; Pentatricopeptide repeat; RNA; Molecular biology; Cell biology; Gene; RNA editing; Genetics; RNase P","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001511782,0.0004460041,0.0002863166,0.0002868773,0.0001969813,0.0004190541,0.0001339805,0.0004464435,0.0007380012],"category_scores_gemma":[0.0001798888,0.0001119982,0.000287438,0.000178701,0.0002334831,0.0002847255,0.0002827039,0.0003714568,0.0004492887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003244575,"about_ca_system_score_gemma":0.0002582348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003421704,"about_ca_topic_score_gemma":0.0002708177,"domain_scores_codex":[0.9999157,0.00001299563,0.000005538436,0.00003769629,0.00001738796,0.00001070753],"domain_scores_gemma":[0.9998791,0.00001756475,0.00002404685,0.00001071864,0.00001866092,0.00004980975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001514505,0.00002450068,0.001872853,0.00007586711,0.0000137021,0.0005532508,0.00002819677,0.00007943703,0.9918794,0.0002182614,0.0001183897,0.004984606],"study_design_scores_gemma":[0.00004080536,0.0004439595,0.01992169,0.00001877844,0.00005141847,0.006225351,0.0000776906,0.00267052,0.9495552,0.0003513031,0.02062253,0.00002090277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9626486,0.01932498,0.01443546,0.0006423225,0.00008175519,0.00005276161,0.000682427,0.0001424473,0.001989184],"genre_scores_gemma":[0.9751186,0.004392991,0.01376238,0.0002525758,0.00005529289,0.00003688757,0.002815728,0.00002524251,0.003540153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007380012,"threshold_uncertainty_score":0.002468824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03161873509638176,"score_gpt":0.3320406813477624,"score_spread":0.3004219462513806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}