{"id":"W2258138802","doi":"10.1002/anie.201510675","title":"Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"Australian Research Council; State Government of Victoria","keywords":"Cubane; Bioisostere; Geology; Chemistry; Crystallography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001611071,0.0003077331,0.0003873548,0.0003199985,0.0003700414,0.0007280181,0.0006169819,0.0007145808,0.002403956],"category_scores_gemma":[0.001698101,0.0001594939,0.0002362029,0.0002316325,0.00160558,0.001401542,0.0009066681,0.001147862,0.000481122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005186161,"about_ca_system_score_gemma":0.0007571115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00114634,"about_ca_topic_score_gemma":0.0008746326,"domain_scores_codex":[0.9993823,0.0002346646,0.00003249888,0.00009079098,0.0001369639,0.0001227588],"domain_scores_gemma":[0.9991875,0.0004112486,0.00008153683,0.0001009576,0.0001428037,0.00007582534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004615782,0.0006777368,0.003934153,0.0009385739,0.00009778601,0.001702059,0.0007396401,0.004422445,0.8012851,0.1001829,0.003518137,0.07788568],"study_design_scores_gemma":[0.0001841871,0.005961164,0.001764167,0.0001216372,0.00007009246,0.0008646173,0.0005804472,0.005656788,0.914869,0.01321015,0.05663426,0.00008331484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9100667,0.010571,0.03234877,0.006277492,0.0008585159,0.0004017887,0.0005020916,0.0001539168,0.03881986],"genre_scores_gemma":[0.9799528,0.004678353,0.008161895,0.001178887,0.00006323478,0.0001116056,0.0001844261,0.00002238722,0.005646586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002403956,"threshold_uncertainty_score":0.008520246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04138783950913441,"score_gpt":0.2751303973813545,"score_spread":0.2337425578722201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}