{"id":"W2258216786","doi":"10.1158/2326-6066.cir-15-0118","title":"Phase I Study of Random Healthy Donor–Derived Allogeneic Natural Killer Cell Therapy in Patients with Malignant Lymphoma or Advanced Solid Tumors","year":2016,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"NKG2D; Medicine; Immune system; Immunotherapy; CD8; Immunology; Lymphoma; Cancer research; In vivo; Cancer; Ex vivo; Cytotoxic T cell; Natural killer cell; Cancer immunotherapy; Cell therapy; Cell; In vitro; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001152344,0.001299291,0.002146076,0.000435945,0.0004094425,0.0005329072,0.0006132305,0.0008256783,0.001761561],"category_scores_gemma":[0.0005039232,0.0003809803,0.0007698892,0.0003435225,0.0008909891,0.000469558,0.0004286354,0.001661017,0.0005467992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005619724,"about_ca_system_score_gemma":0.001253235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004085104,"about_ca_topic_score_gemma":0.0005540396,"domain_scores_codex":[0.9995521,0.0001823889,0.00002164017,0.00009128961,0.00004377968,0.0001088135],"domain_scores_gemma":[0.9996483,0.00005198099,0.00004330089,0.00006093721,0.00002311244,0.0001724166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3467096,0.2287728,0.01416823,0.0007470128,0.000933615,0.001274114,0.0007427428,0.005059415,0.255201,0.00103351,0.003050999,0.1423069],"study_design_scores_gemma":[0.1229953,0.8495797,0.008335518,0.00001542291,0.0002385901,0.0005678589,0.00006160749,0.001309157,0.01430979,0.0002177291,0.002350885,0.00001845831],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994579,0.001048241,0.0007972741,0.0001356659,0.00006729213,0.002253931,0.0002050452,0.00005618389,0.0008573773],"genre_scores_gemma":[0.9928415,0.000854422,0.001465606,0.0002813789,0.0001181714,0.002567511,0.000730619,0.00001715141,0.001123627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002146076,"threshold_uncertainty_score":0.006094217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02961590419996368,"score_gpt":0.3443824299722079,"score_spread":0.3147665257722442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}