{"id":"W2258569606","doi":"10.1093/toxsci/kfv220","title":"Effects of Neonicotinoids on Promoter-Specific Expression and Activity of Aromatase (CYP19) in Human Adrenocortical Carcinoma (H295R) and Primary Umbilical Vein Endothelial (HUVEC) Cells","year":2015,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Insect and Pesticide Research","field":"Agricultural and Biological Sciences","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"","keywords":"Aromatase; Thiacloprid; Endocrinology; Umbilical vein; Internal medicine; Biology; Cancer; Medicine; Thiamethoxam; Breast cancer; Biochemistry; Imidacloprid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004016872,0.000266654,0.0003778203,0.0002003628,0.0001611189,0.0002721958,0.0001759335,0.0002039399,0.0008626744],"category_scores_gemma":[0.0004139813,0.0002035746,0.0004321468,0.0002954068,0.0002236229,0.0001376502,0.0001896277,0.0004451227,0.0003408219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003775872,"about_ca_system_score_gemma":0.0003023271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003383264,"about_ca_topic_score_gemma":0.005153217,"domain_scores_codex":[0.999335,0.00009985688,0.00009488892,0.0001866569,0.000215437,0.00006812538],"domain_scores_gemma":[0.9997501,0.00007143596,0.00005497049,0.00003336183,0.00006797518,0.00002224595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006549102,0.00001519501,0.0002842869,0.00005665031,0.000006798189,0.0000208622,0.00003996314,0.0001002181,0.9980955,0.00003358603,0.0000607896,0.001220786],"study_design_scores_gemma":[0.000008274078,0.0002100511,0.004822977,0.000007294415,0.0000214209,0.00007500689,0.00004506235,0.0007984473,0.9911532,0.00001685797,0.002832895,0.000008512029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96975,0.008202453,0.01345238,0.00022826,0.0001712518,0.0001662474,0.004070865,0.0002745957,0.003684079],"genre_scores_gemma":[0.9657379,0.00444401,0.0174386,0.0002143504,0.00002790256,0.0003256407,0.005825613,0.00007905488,0.005906889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003383264,"threshold_uncertainty_score":0.006727159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04947637601934386,"score_gpt":0.2768110931838086,"score_spread":0.2273347171644648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}