{"id":"W2258573009","doi":"10.1016/j.cell.2016.01.029","title":"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing","year":2016,"lang":"en","type":"article","venue":"Cell","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":612,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; University of Toronto; Canadian Institute for Advanced Research; McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canada Excellence Research Chairs, Government of Canada; National Human Genome Research Institute; National Institute of Mental Health; Natural Sciences and Engineering Research Council of Canada; Krembil Foundation; Canada Foundation for Innovation; National Institutes of Health; Canada Research Chairs; National Institute of General Medical Sciences; Lawrence Ellison Foundation; National Cancer Institute; National Science Foundation","keywords":"Biology; Computational biology; Alternative splicing; RNA splicing; Protein–protein interaction; Genetics; Gene; Exon; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004275601,0.0003414843,0.000428594,0.0007814335,0.0002725825,0.001034508,0.0004315313,0.0004476744,0.001803187],"category_scores_gemma":[0.0004469751,0.0002645282,0.0005442226,0.0005744846,0.0005564643,0.0007634254,0.0007288255,0.0008531461,0.001037465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002635068,"about_ca_system_score_gemma":0.0001473941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001052097,"about_ca_topic_score_gemma":0.0001895831,"domain_scores_codex":[0.9996321,0.00004386612,0.0000346308,0.0001250447,0.0001142772,0.00004999139],"domain_scores_gemma":[0.9989771,0.0002824889,0.0001619481,0.0003216453,0.0001063119,0.0001505783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004018239,0.00000559158,0.0004829266,0.00001251223,0.000007331707,0.0001058089,0.00001328127,0.00003561344,0.99611,0.0005519468,0.00002741675,0.002607309],"study_design_scores_gemma":[0.00001800344,0.0001819332,0.03986913,0.00001053547,0.00006341242,0.004730285,0.00008400693,0.001812136,0.9418,0.002589498,0.008818018,0.00002302494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753628,0.002653003,0.01589362,0.000174159,0.00003471682,0.0000139873,0.0004478495,0.0004275886,0.004992147],"genre_scores_gemma":[0.9919721,0.0006589415,0.00471669,0.00007763143,0.00004066605,0.00001981268,0.0007644151,0.00008760987,0.001662126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001803187,"threshold_uncertainty_score":0.006032288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009222904371418325,"score_gpt":0.2301636504528772,"score_spread":0.2209407460814589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}