{"id":"W2258573009","doi":"10.1016/j.cell.2016.01.029","title":"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing","year":2016,"lang":"en","type":"article","venue":"Cell","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":612,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; University of Toronto; Canadian Institute for Advanced Research; McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canada Excellence Research Chairs, Government of Canada; National Human Genome Research Institute; National Institute of Mental Health; Natural Sciences and Engineering Research Council of Canada; Krembil Foundation; Canada Foundation for Innovation; National Institutes of Health; Canada Research Chairs; National Institute of General Medical Sciences; Lawrence Ellison Foundation; National Cancer Institute; National Science Foundation","keywords":"Biology; Computational biology; Alternative splicing; RNA splicing; Protein–protein interaction; Genetics; Gene; Exon; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009711381,0.00007814884,0.00008028309,0.00001696138,0.00002058987,0.000004377262,0.00008690721,0.00006239173,0.00005932617],"category_scores_gemma":[0.00005485521,0.00005430391,0.00004321364,0.00001589998,0.00003556813,0.000004749919,0.00003623997,0.00002001239,0.0000126939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001027559,"about_ca_system_score_gemma":0.00001518497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005451308,"about_ca_topic_score_gemma":0.000002969733,"domain_scores_codex":[0.9994836,0.00005104654,0.0001252999,0.0001730149,0.00006858327,0.00009840432],"domain_scores_gemma":[0.9996371,0.00002064362,0.00008695134,0.0001848973,0.00004324994,0.00002711398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005508617,0.0000189965,0.00002795997,0.00001918495,0.000006481526,2.291861e-7,0.00005542731,9.332892e-7,0.9923294,0.00003136483,0.0002948581,0.007160132],"study_design_scores_gemma":[0.0001900041,0.0002007603,0.000007002707,0.00007521092,0.000003379043,9.322174e-7,0.0001042571,0.000002665133,0.9930223,0.0003897855,0.00592591,0.00007781688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877558,0.0002121153,0.01005577,0.0000587666,0.0001002583,0.0001773883,0.00001260351,0.000005661989,0.001621591],"genre_scores_gemma":[0.9954028,0.00005382374,0.0004891998,0.00002157741,0.00006095982,0.00003209584,0.000006520981,0.00001153389,0.003921559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009566573,"threshold_uncertainty_score":0.2214449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009222904371418325,"score_gpt":0.2301636504528772,"score_spread":0.2209407460814589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}