{"id":"W2258700589","doi":"10.1126/science.aaf1929","title":"(TORC)ing up purine biosynthesis","year":2016,"lang":"en","type":"letter","venue":"Science","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Biosynthesis; Nucleotide; Purine; Biochemistry; Enzyme; Chemistry; Purine metabolism; Metabolism; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004113174,0.0002365998,0.0001700588,0.0001295358,0.0001738635,0.00008935235,0.001263488,0.0004956018,0.0001165527],"category_scores_gemma":[0.0003605851,0.0001701692,0.0001348396,0.0002467864,0.001094681,0.000004708184,0.0006939172,0.0004251061,0.0001901835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003863145,"about_ca_system_score_gemma":0.0003622257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007136037,"about_ca_topic_score_gemma":9.722318e-7,"domain_scores_codex":[0.9973963,0.00004262443,0.0001680621,0.0009281208,0.0006664703,0.0007984219],"domain_scores_gemma":[0.9987836,0.00001664154,0.00007086711,0.0008136184,0.0001780815,0.0001371388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005111125,0.000003246024,0.000009082853,0.00001920194,0.000008276212,0.00001891419,0.000001778479,1.840941e-8,0.6802386,0.0000044008,0.3146555,0.005035951],"study_design_scores_gemma":[0.00005650803,0.0000321587,0.000008625425,0.00002501753,0.000003614772,0.00001214972,9.000419e-7,6.68238e-7,0.4756793,0.00004504942,0.5239846,0.0001513808],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03690252,0.002724594,0.001120294,0.9390684,0.001896215,0.0006152298,0.0001600987,0.00007593107,0.01743666],"genre_scores_gemma":[0.1019965,0.000969852,0.001137442,0.7769807,0.01686176,0.0001242871,0.00030857,0.0001818864,0.101439],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2093292,"threshold_uncertainty_score":0.6939298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01484972181566249,"score_gpt":0.2795895578262053,"score_spread":0.2647398360105427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}