{"id":"W2258700589","doi":"10.1126/science.aaf1929","title":"(TORC)ing up purine biosynthesis","year":2016,"lang":"en","type":"letter","venue":"Science","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Biosynthesis; Nucleotide; Purine; Biochemistry; Enzyme; Chemistry; Purine metabolism; Metabolism; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005072339,0.0008108952,0.0005679227,0.000282075,0.001192953,0.001824352,0.0005579545,0.006789141,0.01621888],"category_scores_gemma":[0.002167633,0.0002365868,0.0007251,0.0001912295,0.001094242,0.0008201657,0.0009138106,0.008265733,0.02099963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002207611,"about_ca_system_score_gemma":0.0008182251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001220589,"about_ca_topic_score_gemma":0.001916316,"domain_scores_codex":[0.9995531,0.00007791545,0.00003525817,0.00008072378,0.0001355812,0.0001173439],"domain_scores_gemma":[0.9994928,0.0001501616,0.00004506132,0.00006165721,0.0001403375,0.0001099638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004788503,0.00004421456,0.0005193208,0.0002219952,0.000033487,0.004051375,0.00003917268,0.0002154682,0.00367271,0.01838385,0.9145628,0.05777683],"study_design_scores_gemma":[0.0001632075,0.0001038098,0.0005102231,0.00008520661,0.00002095592,0.003233914,0.00006668791,0.0004847794,0.004478081,0.01046827,0.9803565,0.00002826508],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.007190315,0.0252494,0.00268714,0.743894,0.1009075,0.0002186945,0.001078775,0.0009988011,0.1177755],"genre_scores_gemma":[0.1175597,0.0203809,0.004290655,0.5575744,0.06661157,0.0005495063,0.001072616,0.0001542919,0.2318064],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.01621888,"threshold_uncertainty_score":0.05425751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01484972181566249,"score_gpt":0.2795895578262053,"score_spread":0.2647398360105427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}