{"id":"W2258857075","doi":"10.1074/jbc.m115.704809","title":"Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Toronto; Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Cystic Fibrosis Foundation Therapeutics; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Cystic fibrosis transmembrane conductance regulator; ATP-binding cassette transporter; Gating; Cyclic nucleotide-binding domain; Transmembrane domain; Chemistry; Cystic fibrosis; Cell biology; Transmembrane protein; ATP hydrolysis; Chloride channel; Biochemistry; Biophysics; Transporter; Medicine; Biology; Peptide sequence; ATPase; Internal medicine; Membrane; Receptor; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001517518,0.0002010874,0.0003495152,0.00009941621,0.0001866693,0.0003265743,0.000196895,0.0003405042,0.0008083146],"category_scores_gemma":[0.000267543,0.00007282343,0.0001784706,0.00007875133,0.0002747481,0.0001856363,0.0001760619,0.0003668304,0.0002192126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003742657,"about_ca_system_score_gemma":0.0002073146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000619296,"about_ca_topic_score_gemma":0.000727078,"domain_scores_codex":[0.9997427,0.00004418204,0.00001477655,0.00005786452,0.00008239106,0.00005818459],"domain_scores_gemma":[0.9998502,0.00004764555,0.00004016958,0.00001661028,0.00001946764,0.00002593017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007306798,0.000007502539,0.0001444954,0.00001781171,0.000001330841,0.00005746587,0.000008605511,0.00003760407,0.9990003,0.00003742676,0.00001816447,0.0005963229],"study_design_scores_gemma":[0.00002134084,0.0001919164,0.006778699,0.000005302352,0.000007854812,0.0006311314,0.00002274203,0.0008715946,0.9897786,0.00003845391,0.001643945,0.000008375378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930861,0.002872722,0.002784419,0.0001670502,0.00004610375,0.0000285311,0.0001480666,0.00005028794,0.0008167262],"genre_scores_gemma":[0.9977486,0.000526062,0.001085253,0.00006487645,0.000008265959,0.00001485798,0.0001466233,0.000008249578,0.0003973219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008083146,"threshold_uncertainty_score":0.002715528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04465806073090516,"score_gpt":0.2985772793981509,"score_spread":0.2539192186672458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}