{"id":"W2259127335","doi":"10.1158/1078-0432.ccr-15-2218","title":"Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre","funders":"National Cancer Institute; Universitat de Girona; Astellas Pharma US","keywords":"Medicine; Erlotinib; Internal medicine; Pharmacodynamics; Adverse effect; Nausea; Epidermal growth factor receptor; Oncology; Insulin-like growth factor 1 receptor; Cohort; Vomiting; Cancer; Pharmacology; Pharmacokinetics; Gastroenterology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007206132,0.0001113502,0.0004069033,0.0001685515,0.00006707672,0.000009523602,0.00007130003,0.00006297772,0.00009710879],"category_scores_gemma":[0.0004178386,0.000063823,0.0000348183,0.000362424,0.0002547273,0.0001184761,0.00005720131,0.0002619917,0.000006664952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00015433,"about_ca_system_score_gemma":0.0003711381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002184883,"about_ca_topic_score_gemma":0.0003750768,"domain_scores_codex":[0.9979081,0.0002172728,0.0005797739,0.0004164003,0.0005798752,0.0002986309],"domain_scores_gemma":[0.9982997,0.000570517,0.0001177704,0.0002974532,0.0005079349,0.0002065891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005504685,0.006881079,0.8046775,0.00003690427,0.0000932175,0.00001551134,0.0005171261,0.000002642058,0.0001065878,0.00001600797,0.00007822144,0.1820705],"study_design_scores_gemma":[0.05747981,0.01584008,0.925254,0.0004523149,0.00006323127,4.148794e-7,0.0003974335,0.00001637742,0.0001611058,0.00004053951,0.0002148843,0.00007984562],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968762,0.0001092144,0.000009964662,0.0006673242,0.00006463721,0.001873147,0.00003787881,0.00001503116,0.0003465427],"genre_scores_gemma":[0.9990876,0.0001299954,0.00009194514,0.00004955346,0.00008758249,0.0002243111,0.00001328622,0.00002279722,0.0002929514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1819906,"threshold_uncertainty_score":0.2602626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1126977391967929,"score_gpt":0.5568681410234685,"score_spread":0.4441704018266757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}