{"id":"W2259127335","doi":"10.1158/1078-0432.ccr-15-2218","title":"Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre","funders":"National Cancer Institute; Universitat de Girona; Astellas Pharma US","keywords":"Medicine; Erlotinib; Internal medicine; Pharmacodynamics; Adverse effect; Nausea; Epidermal growth factor receptor; Oncology; Insulin-like growth factor 1 receptor; Cohort; Vomiting; Cancer; Pharmacology; Pharmacokinetics; Gastroenterology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001532751,0.001230525,0.001646862,0.0003690956,0.0003528848,0.0006382145,0.0007174531,0.0006876555,0.001966165],"category_scores_gemma":[0.0007197912,0.0004960913,0.0009025215,0.0004205309,0.0007552383,0.000725296,0.0003393147,0.003124623,0.000557096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00102668,"about_ca_system_score_gemma":0.001524366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000793863,"about_ca_topic_score_gemma":0.002404868,"domain_scores_codex":[0.9994829,0.0002175804,0.00003119501,0.00008900747,0.00006693598,0.0001123498],"domain_scores_gemma":[0.9994059,0.00006946648,0.0001392303,0.00005593501,0.00003268983,0.0002967776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5757958,0.1339632,0.0216319,0.0006158344,0.001324701,0.0003323387,0.0006362154,0.005091746,0.1036007,0.0003228215,0.004170665,0.1525141],"study_design_scores_gemma":[0.3377501,0.6103095,0.03390443,0.00002913761,0.0004119304,0.0004863317,0.00008570342,0.002818246,0.01091984,0.0001599332,0.003094857,0.00002997716],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974758,0.0005410013,0.0002160858,0.0001233354,0.00003190916,0.0007581331,0.0002355767,0.00004243818,0.0005757507],"genre_scores_gemma":[0.9962863,0.0003474365,0.0008394928,0.0002272619,0.00004864015,0.000684631,0.0007545099,0.00001026753,0.0008014554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001966165,"threshold_uncertainty_score":0.008106053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1126977391967929,"score_gpt":0.5568681410234685,"score_spread":0.4441704018266757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}