{"id":"W2259167207","doi":"10.1016/j.virol.2016.01.012","title":"PI3K-Akt signaling pathway upregulates hepatitis C virus RNA translation through the activation of SREBPs","year":2016,"lang":"en","type":"article","venue":"Virology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Saskatchewan","keywords":"Protein kinase B; PI3K/AKT/mTOR pathway; Biology; Sterol regulatory element-binding protein; Phosphorylation; Wortmannin; AKT1; Signal transduction; Cell biology; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003163797,0.0001277312,0.0002856476,0.0000911974,0.00008805269,0.000006728861,0.0001302394,0.0001798572,0.000430262],"category_scores_gemma":[0.0002403786,0.00007282579,0.00009034039,0.000200222,0.0002719105,0.0001746376,0.00003005493,0.0001641252,0.0001000011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005657344,"about_ca_system_score_gemma":0.00009723969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001325137,"about_ca_topic_score_gemma":0.0002643813,"domain_scores_codex":[0.9985393,0.0002406018,0.0003560758,0.0002416661,0.0003233684,0.0002989647],"domain_scores_gemma":[0.9987667,0.0005913137,0.0001216739,0.000342609,0.0001236832,0.00005397314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001989626,0.00005757902,0.006737432,0.00002521476,0.00006100352,0.000008579632,0.0006656184,0.00001610142,0.8577783,0.0009456623,0.0001581014,0.1333474],"study_design_scores_gemma":[0.001384039,0.000652726,0.02954596,0.00009613147,0.00003538377,0.00001134743,0.00002205399,0.0003737253,0.9496864,0.00301243,0.01506981,0.0001099543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806112,0.0001814243,0.01067515,0.0062021,0.00008473133,0.0004284586,0.00002896576,0.00009769857,0.001690287],"genre_scores_gemma":[0.9983466,0.0002694749,0.0005884115,0.0004066311,0.0001515348,0.00004157939,0.00001149737,0.00004411495,0.0001401411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1332375,"threshold_uncertainty_score":0.4711067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04811173060816473,"score_gpt":0.3096468698143905,"score_spread":0.2615351392062257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}