{"id":"W2259397374","doi":"10.1371/journal.pone.0148439","title":"OGR1/GPR68 Modulates the Severity of Experimental Autoimmune Encephalomyelitis and Regulates Nitric Oxide Production by Macrophages","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto; University Health Network","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; University Health Network","keywords":"Experimental autoimmune encephalomyelitis; Myelin oligodendrocyte glycoprotein; Autoimmunity; Biology; Knockout mouse; Nitric oxide; Immunology; Encephalomyelitis; Inflammation; T cell; Cell biology; Receptor; Multiple sclerosis; Endocrinology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001895048,0.0003929448,0.0003751891,0.0003173556,0.0001254009,0.0001957139,0.0001700794,0.0003797196,0.0008243235],"category_scores_gemma":[0.0001365223,0.0001415971,0.0002617605,0.0001245228,0.0003503184,0.0003013964,0.000231802,0.0007467382,0.000224398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000152468,"about_ca_system_score_gemma":0.0001242347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001851841,"about_ca_topic_score_gemma":0.0002420959,"domain_scores_codex":[0.9998034,0.00004134277,0.00001682158,0.00003360211,0.00002639012,0.00007853909],"domain_scores_gemma":[0.9998757,0.000006545294,0.00004729126,0.000008512658,0.00001008524,0.00005178962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002042348,0.000107851,0.001097963,0.00005045718,0.000009229977,0.0001193297,0.00002946301,0.00005347424,0.9945702,0.00005237783,0.00005083256,0.001816419],"study_design_scores_gemma":[0.0005093341,0.005659362,0.1466961,0.00004906186,0.000198764,0.001420358,0.0004290911,0.002092599,0.8394574,0.0004463838,0.003003454,0.00003817751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984611,0.0008060968,0.0002948332,0.00007264311,0.00001826011,0.000008248591,0.00007297299,0.00001585804,0.0002501172],"genre_scores_gemma":[0.997928,0.0007037294,0.0003187934,0.00006336987,0.00001655432,0.00002499513,0.0001159225,0.000007291835,0.0008213448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008243235,"threshold_uncertainty_score":0.002757668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01152067109524797,"score_gpt":0.2044551003238833,"score_spread":0.1929344292286353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}