{"id":"W2259492344","doi":"10.1038/leu.2016.22","title":"Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers","year":2016,"lang":"en","type":"article","venue":"Leukemia","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Minor histocompatibility antigen; Human leukocyte antigen; Immunotherapy; Immunology; Biology; Haematopoiesis; Histocompatibility; Haplotype; Antigen; Major histocompatibility complex; Allele; Immune system; Stem cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002837686,0.0002260944,0.000586582,0.0001019256,0.0001044494,0.00000583949,0.0003099159,0.0002197911,0.0001407731],"category_scores_gemma":[0.00006379927,0.0001319415,0.0001919198,0.0001046951,0.0006194271,0.0001247351,0.00002006917,0.0001046009,0.000005583963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003889465,"about_ca_system_score_gemma":0.0008816076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008479492,"about_ca_topic_score_gemma":0.00008637321,"domain_scores_codex":[0.9986961,0.0001695971,0.0004346804,0.0002941343,0.00004297429,0.0003625338],"domain_scores_gemma":[0.9984068,0.0005008208,0.0004019146,0.0005553399,0.0001259016,0.000009245493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01111187,0.00009712637,0.007750395,0.0001262348,0.000288984,6.429249e-7,0.0002315906,0.00002331291,0.9763712,0.0002972891,0.0004780851,0.003223277],"study_design_scores_gemma":[0.005207454,0.001095062,0.02554545,0.0001866507,0.00002908668,0.00001402104,0.00007640002,0.000001140085,0.9619743,0.00008812139,0.005580712,0.0002016342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987738,0.006913404,0.003541483,0.00009265432,0.0001711953,0.001201277,0.0002088978,0.00003113306,0.0001019645],"genre_scores_gemma":[0.9949386,0.00007801045,0.0007962949,0.0000663279,0.000007555671,0.0001797105,0.00002771446,0.00002682357,0.00387894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01779506,"threshold_uncertainty_score":0.538042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01168216334939313,"score_gpt":0.2376178965452023,"score_spread":0.2259357331958092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}