{"id":"W2259804540","doi":"10.1038/ncomms10156","title":"The experimental power of FR900359 to study Gq-regulated biological processes","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":372,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; McGill University Health Centre","funders":"Precursory Research for Embryonic Science and Technology; Core Research for Evolutional Science and Technology; Division of Materials Research; National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; Medical Research Council; Università degli Studi di Ferrara; Deutsche Forschungsgemeinschaft; Japan Agency for Medical Research and Development; Biotechnology and Biological Sciences Research Council; Strategiske Forskningsråd","keywords":"Heterotrimeric G protein; Pertussis toxin; Gene isoform; G protein; Gs alpha subunit; Cell biology; G protein-coupled receptor; Chemistry; Biology; Computational biology; Signal transduction; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004615606,0.0003430245,0.0002013124,0.0002382331,0.0001879773,0.0002557598,0.0003038783,0.0004423679,0.001165809],"category_scores_gemma":[0.0002273054,0.0001223534,0.000312031,0.0001561527,0.0004139188,0.0003144074,0.0002967643,0.00105784,0.0002547554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003591048,"about_ca_system_score_gemma":0.0002788696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000782095,"about_ca_topic_score_gemma":0.0008203537,"domain_scores_codex":[0.99985,0.00002966711,0.000009463431,0.00004063029,0.00004940513,0.00002074652],"domain_scores_gemma":[0.9998771,0.00003851213,0.00002350885,0.00002798204,0.00001098396,0.00002193591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008599344,0.00003005062,0.00007166626,0.00002525508,0.000004874449,0.00002310133,0.000008700889,0.00009929249,0.9971003,0.0005331878,0.00004245628,0.001975136],"study_design_scores_gemma":[0.0000615364,0.0009620529,0.001508332,0.00000790582,0.00001572821,0.0002933395,0.0000121069,0.0006438969,0.9909944,0.0003268714,0.005166636,0.000007162845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9402174,0.006563029,0.04347361,0.000982533,0.0001693558,0.0002776451,0.0009873781,0.0002820104,0.007047132],"genre_scores_gemma":[0.9551573,0.00511348,0.03648154,0.0003816098,0.00006324044,0.0001699844,0.0008334037,0.00005693222,0.001742619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001165809,"threshold_uncertainty_score":0.003899992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05106921375695327,"score_gpt":0.3837774808420719,"score_spread":0.3327082670851186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}