{"id":"W2259804540","doi":"10.1038/ncomms10156","title":"The experimental power of FR900359 to study Gq-regulated biological processes","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":372,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; McGill University Health Centre","funders":"Precursory Research for Embryonic Science and Technology; Core Research for Evolutional Science and Technology; Division of Materials Research; National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; Medical Research Council; Università degli Studi di Ferrara; Deutsche Forschungsgemeinschaft; Japan Agency for Medical Research and Development; Biotechnology and Biological Sciences Research Council; Strategiske Forskningsråd","keywords":"Heterotrimeric G protein; Pertussis toxin; Gene isoform; G protein; Gs alpha subunit; Cell biology; G protein-coupled receptor; Chemistry; Biology; Computational biology; Signal transduction; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003106097,0.00007383148,0.00007282443,0.00002928842,0.0001784961,0.00002154195,0.0008804522,0.0001381144,0.000009035921],"category_scores_gemma":[0.0008225753,0.00004827357,0.00002727208,0.0002702795,0.0001217376,0.000002576151,0.0005499733,0.0002007454,0.00001045334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001177046,"about_ca_system_score_gemma":0.0001052114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000918734,"about_ca_topic_score_gemma":0.0001308423,"domain_scores_codex":[0.9992533,0.0001770592,0.0001490283,0.0001388813,0.0001646215,0.0001171211],"domain_scores_gemma":[0.9982578,0.00004235114,0.00004347912,0.001110026,0.0004609301,0.00008541213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001041973,0.00489628,0.03975458,0.000008823105,0.0003500525,0.000002861146,0.003983728,0.00006010004,0.8995954,0.003122567,0.04260089,0.004582764],"study_design_scores_gemma":[0.001283665,0.002143981,0.02390932,0.000009508607,0.000009409152,0.000008114329,0.00914026,0.00003070016,0.4990665,0.00009173106,0.4640566,0.0002501911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885504,0.006635834,0.00002947164,0.001815477,0.00004609918,0.0005655468,0.00001030554,0.00001240497,0.002334484],"genre_scores_gemma":[0.998681,0.00006787228,0.0007077187,0.0001319413,0.00001673029,0.0001019813,0.00005046238,0.000007430013,0.0002348724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4214557,"threshold_uncertainty_score":0.1968539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05106921375695327,"score_gpt":0.3837774808420719,"score_spread":0.3327082670851186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}