{"id":"W2259828625","doi":"10.1200/jco.2005.23.16_suppl.7017","title":"Oral topotecan demonstrates clinical activity in relapsed non-small cell lung cancer. Results from an open-label, phase III study (387) comparing oral topotecan to intravenous docetaxel","year":2005,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Topotecan; Docetaxel; Medicine; Maximum tolerated dose; Lung cancer; Oncology; Internal medicine; Phases of clinical research; Cancer; Pharmacology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001783489,0.00100998,0.002874389,0.000503367,0.0004613487,0.001235904,0.00114272,0.00106697,0.003319488],"category_scores_gemma":[0.001681086,0.0006330798,0.001520986,0.0006648809,0.001316509,0.0008373201,0.0002099313,0.003866035,0.0008460185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001391891,"about_ca_system_score_gemma":0.001675016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003831963,"about_ca_topic_score_gemma":0.008442616,"domain_scores_codex":[0.9992061,0.0004012769,0.00004127522,0.00008011621,0.0001080533,0.0001631427],"domain_scores_gemma":[0.9983926,0.0006845249,0.0002174632,0.0001102909,0.0000770467,0.000518124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6997952,0.03770782,0.006276298,0.00148105,0.002942133,0.0005972296,0.0003524421,0.002429937,0.06232795,0.0003930051,0.006831939,0.178865],"study_design_scores_gemma":[0.3801604,0.575355,0.02526828,0.00009031193,0.001600962,0.0006556109,0.0001076636,0.001385544,0.01127434,0.0001972201,0.003840274,0.00006448218],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909267,0.004928797,0.0003020595,0.0002929057,0.0001164278,0.0005143823,0.0008926083,0.00007913038,0.001946965],"genre_scores_gemma":[0.9921234,0.00333561,0.0005465045,0.0002724115,0.0001708295,0.0002169962,0.001843981,0.00003768204,0.001452538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003831963,"threshold_uncertainty_score":0.01110482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2571557998899412,"score_gpt":0.5700849347029274,"score_spread":0.3129291348129862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}