{"id":"W2259926819","doi":"10.1038/ncomms9036","title":"Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Santander Universities; Ontario Institute for Cancer Research; Ministerio de Economía y Competitividad; Howard Hughes Medical Institute; Agence Nationale de la Recherche; Banco Santander","keywords":"Reprogramming; Induced pluripotent stem cell; Genome instability; Somatic cell; Biology; Cell biology; DNA re-replication; DNA replication; Genetics; DNA damage; Cell; Control of chromosome duplication; Gene; Embryonic stem cell; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002002743,0.0005039037,0.0003545308,0.0002894952,0.0001472602,0.0004659689,0.0002526158,0.0003298328,0.001313637],"category_scores_gemma":[0.0002710879,0.0001388587,0.0002911896,0.0001911958,0.0001883104,0.0002968411,0.0003139673,0.0006199077,0.0003611405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002262949,"about_ca_system_score_gemma":0.0002393543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002738266,"about_ca_topic_score_gemma":0.0003992239,"domain_scores_codex":[0.9997594,0.00004492211,0.00003799865,0.00005458078,0.00006880234,0.00003436122],"domain_scores_gemma":[0.9997714,0.00004177416,0.000103877,0.00002785159,0.00002452771,0.00003051568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002486905,0.00001039792,0.00005353044,0.00003039216,0.00000333929,0.00001257224,0.000005629592,0.00006293518,0.9987671,0.00004008924,0.00001692949,0.0009722061],"study_design_scores_gemma":[0.000003673448,0.0001399419,0.001016442,0.000006731074,0.00001413627,0.00005951553,0.000008940138,0.000242493,0.9971636,0.00004163218,0.001298673,0.00000424925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747537,0.007309422,0.0139223,0.0003258019,0.0001262561,0.00008911856,0.0007118793,0.0003311892,0.002430156],"genre_scores_gemma":[0.9899665,0.00251198,0.00481678,0.0001115974,0.00002784961,0.00005316883,0.0006794245,0.00008520283,0.001747431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313637,"threshold_uncertainty_score":0.004394531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04462835567819749,"score_gpt":0.3115045913274265,"score_spread":0.266876235649229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}