{"id":"W2259926819","doi":"10.1038/ncomms9036","title":"Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Santander Universities; Ontario Institute for Cancer Research; Ministerio de Economía y Competitividad; Howard Hughes Medical Institute; Agence Nationale de la Recherche; Banco Santander","keywords":"Reprogramming; Induced pluripotent stem cell; Genome instability; Somatic cell; Biology; Cell biology; DNA re-replication; DNA replication; Genetics; DNA damage; Cell; Control of chromosome duplication; Gene; Embryonic stem cell; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008801878,0.0001830165,0.0001860646,0.0001353182,0.0002017474,0.00006796621,0.001335618,0.0003910801,0.000001447245],"category_scores_gemma":[0.0002322645,0.0001960199,0.00007847415,0.0003370062,0.00009112696,0.00001771666,0.001069276,0.0008309588,0.00001426812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002141761,"about_ca_system_score_gemma":0.0002116805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007265798,"about_ca_topic_score_gemma":0.0004630176,"domain_scores_codex":[0.9978706,0.000414063,0.0004803461,0.0006116135,0.0002660539,0.0003572857],"domain_scores_gemma":[0.9956306,0.00005990372,0.0002206964,0.003674151,0.0002572644,0.0001574278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003096312,0.0002744857,0.01958509,0.00005407598,0.00001537959,0.000001530616,0.0003167387,0.0001650855,0.976913,0.00001698728,0.00003525506,0.0025914],"study_design_scores_gemma":[0.0006951676,0.00007153974,0.01973986,0.00005850881,0.00001264278,0.000007918416,0.001693613,0.0006968277,0.9746417,0.00002445757,0.002095887,0.0002618348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992724,0.004713625,0.00001733218,0.0005939311,0.00008466,0.0006837571,0.00001740535,0.00004123098,0.00112405],"genre_scores_gemma":[0.9963573,0.0004626543,0.002568606,0.00003358434,0.00006097232,0.0001591745,0.0001769929,0.00003314514,0.0001476096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004250971,"threshold_uncertainty_score":0.7993458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04462835567819749,"score_gpt":0.3115045913274265,"score_spread":0.266876235649229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}