{"id":"W2260123348","doi":"10.1007/s00428-016-1904-2","title":"In prostate cancer needle biopsies, detections of PTEN loss by fluorescence in situ hybridization (FISH) and by immunohistochemistry (IHC) are concordant and show consistent association with upgrading","year":2016,"lang":"en","type":"article","venue":"Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Cancer Institute; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"PTEN; Immunohistochemistry; Tensin; Fluorescence in situ hybridization; Prostate cancer; Concordance; Biology; In situ hybridization; Cancer; Pathology; Biopsy; Cancer research; Medicine; Gene; Bioinformatics; Genetics; Gene expression; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009123929,0.0007278211,0.0004908555,0.002237331,0.000386911,0.0007188804,0.0005989833,0.0005140973,0.003642631],"category_scores_gemma":[0.002448054,0.0004136315,0.0004504229,0.001043368,0.0008940413,0.0005593763,0.0007120791,0.0004387863,0.001052295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002984244,"about_ca_system_score_gemma":0.0003599629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002676685,"about_ca_topic_score_gemma":0.003549464,"domain_scores_codex":[0.9989219,0.0001264604,0.00008680578,0.0001846848,0.0004946137,0.0001855695],"domain_scores_gemma":[0.9982887,0.0004652973,0.0004432943,0.0001917298,0.0003456525,0.0002652781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001205401,0.0001203102,0.5108059,0.0003343812,0.0002805231,0.006383362,0.0006050961,0.000526761,0.4527269,0.0003933834,0.0005564918,0.02606154],"study_design_scores_gemma":[0.00004030225,0.0005843453,0.8524734,0.0000290188,0.000202838,0.02605342,0.0005303242,0.001346553,0.115254,0.0007064539,0.00274512,0.00003424599],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689218,0.003264248,0.01224082,0.0001704659,0.00005608415,0.0001362097,0.0007333587,0.0007352958,0.0137417],"genre_scores_gemma":[0.9951166,0.0006312981,0.002540116,0.00005519421,0.00001618329,0.00003060823,0.0004303667,0.00003242315,0.001147351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003642631,"threshold_uncertainty_score":0.01218575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01430478099783757,"score_gpt":0.3220447179494752,"score_spread":0.3077399369516376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}