{"id":"W2260206950","doi":"10.4049/jimmunol.188.supp.126.11","title":"ICOS promotes T cell activation and function beyond phosphoinositide 3-kinase signaling (126.11)","year":2012,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"T cell; Cytotoxic T cell; Cell biology; CD8; PI3K/AKT/mTOR pathway; T-cell receptor; CD28; Chemistry; Signal transduction; Biology; Immunology; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001318271,0.0006600296,0.0002223413,0.0003301162,0.0001605571,0.0004824968,0.0002018887,0.0004014313,0.001842027],"category_scores_gemma":[0.00008558979,0.0001199639,0.0002663476,0.0002286891,0.0003268908,0.0002594346,0.000173836,0.0008443096,0.0005312235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003295986,"about_ca_system_score_gemma":0.0002199591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005034773,"about_ca_topic_score_gemma":0.0005884741,"domain_scores_codex":[0.999827,0.00002192532,0.0000189513,0.00003289058,0.00003769029,0.00006159895],"domain_scores_gemma":[0.9997421,0.00002375143,0.0001002787,0.00002280601,0.0000157155,0.00009534719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001257779,0.00004189243,0.0001245309,0.00002870571,0.000002170079,0.0000304165,0.00000668427,0.00004054062,0.998939,0.00009086875,0.00004687762,0.0005225122],"study_design_scores_gemma":[0.00004101784,0.0005140643,0.003440999,0.00001121445,0.00001772861,0.000212623,0.00002589327,0.0005392223,0.9926968,0.00003574154,0.002461076,0.000003520734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950684,0.0007589977,0.001122054,0.00009044383,0.00003909306,0.00002016274,0.000404815,0.000100463,0.002395408],"genre_scores_gemma":[0.9954281,0.0004174155,0.001111002,0.0000526891,0.00002265503,0.00002622662,0.0005161908,0.00002890844,0.002396808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001842027,"threshold_uncertainty_score":0.006162167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009943502122073972,"score_gpt":0.2065685774161928,"score_spread":0.1966250752941188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}