{"id":"W2260261261","doi":"10.1200/jco.2007.25.18_suppl.7577","title":"P53 protein over-expression but not <i>p53</i> gene mutation is a poor prognostic marker and a predictive marker for survival benefit from adjuvant chemotherapy in non-small cell lung cancer (NSCLC) in the JBR.10 Trial","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health; University of Alberta; Health Sciences Centre; University Health Network","funders":"","keywords":"Medicine; Immunohistochemistry; Oncology; Internal medicine; ERCC1; Chemotherapy; Cisplatin; Vinorelbine; Hazard ratio; Lung cancer; Cancer research; Gene; DNA repair; Biology; Nucleotide excision repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002222192,0.0007178166,0.000977125,0.0001940954,0.0001976202,0.0005654339,0.0003469738,0.000599305,0.002151397],"category_scores_gemma":[0.0008232991,0.0002645711,0.0009725754,0.0001790758,0.0005483538,0.0002979076,0.0002113146,0.0014109,0.0003046188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004614783,"about_ca_system_score_gemma":0.0006268104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004615423,"about_ca_topic_score_gemma":0.001730686,"domain_scores_codex":[0.9995332,0.0002880796,0.00002716648,0.00006486258,0.00003232758,0.00005440486],"domain_scores_gemma":[0.9993801,0.0002029139,0.0001396155,0.00004448725,0.00002680504,0.0002060089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9129629,0.004533303,0.02850454,0.0008884291,0.001725949,0.0000925616,0.00008037007,0.0008730132,0.01751215,0.0001146807,0.001780707,0.03093145],"study_design_scores_gemma":[0.5710015,0.2567601,0.14705,0.0003228266,0.007755752,0.0005784343,0.0000814966,0.002580254,0.008934014,0.0004293654,0.004446404,0.0000598909],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955712,0.002586174,0.0001241396,0.000247275,0.00007286351,0.0002275128,0.0002689509,0.00001292376,0.0008890987],"genre_scores_gemma":[0.9956627,0.00131749,0.0003418296,0.0003610037,0.0001602277,0.0002449714,0.0009857108,0.000007537889,0.0009184781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002222192,"threshold_uncertainty_score":0.01175225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02678826403054321,"score_gpt":0.3610615045840602,"score_spread":0.3342732405535169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}