{"id":"W2260324989","doi":"10.1371/journal.pone.0149194","title":"A Comparative Oncology Study of Iniparib Defines Its Pharmacokinetic Profile and Biological Activity in a Naturally-Occurring Canine Cancer Model","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Cancer Institute; National Institutes of Health","keywords":"Medicine; Carboplatin; Internal medicine; Pharmacokinetics; Neutropenia; Tolerability; Adverse effect; Pharmacology; Oncology; Chemotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005717092,0.0004558318,0.0008546343,0.0007138542,0.0003672729,0.0006330476,0.0004883122,0.0005089006,0.001594623],"category_scores_gemma":[0.0005313805,0.0002448754,0.0004162504,0.0005182318,0.0005194368,0.0006938815,0.0002086303,0.001403796,0.0002841988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001394934,"about_ca_system_score_gemma":0.0005890923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001803048,"about_ca_topic_score_gemma":0.002465359,"domain_scores_codex":[0.9995109,0.0001282134,0.00002775184,0.0001215117,0.00008692724,0.0001246597],"domain_scores_gemma":[0.9992744,0.0001164981,0.0001774007,0.0001333514,0.0001064166,0.0001919187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01041129,0.006420253,0.002169474,0.0001547718,0.00006358069,0.0001442394,0.0001455395,0.001030462,0.9688495,0.0004515711,0.0006193737,0.009539887],"study_design_scores_gemma":[0.001185983,0.1574935,0.01809537,0.00001796391,0.000313869,0.001709491,0.0002491941,0.007488133,0.8020015,0.000377009,0.01100725,0.00006068795],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995584,0.0006462777,0.00182581,0.0001065432,0.00004309901,0.0001833044,0.0005316798,0.00004190151,0.001037459],"genre_scores_gemma":[0.9927307,0.0007323584,0.002522923,0.00009312135,0.00003108125,0.0002187491,0.001631579,0.00003842901,0.002001039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001803048,"threshold_uncertainty_score":0.01012093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.265840931105986,"score_gpt":0.4127668320106,"score_spread":0.146925900904614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}