{"id":"W2260339506","doi":"10.1016/j.antiviral.2016.02.006","title":"Statins can exert dual, concentration dependent effects on HCV entry in vitro","year":2016,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Hepatitis C virus research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Pravastatin; Downregulation and upregulation; Atorvastatin; In vitro; In vivo; Pharmacology; Medicine; Statin; Ribavirin; HMG-CoA reductase; Viral entry; Reductase; Hepatitis C virus; Immunology; Cholesterol; Chemistry; Virus; Biology; Internal medicine; Enzyme; Biochemistry; Viral replication","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001712654,0.0001609356,0.0002981177,0.0004035509,0.0001199648,0.00005691485,0.0001622753,0.0001370159,0.00009880686],"category_scores_gemma":[0.003264655,0.0001109397,0.00005688842,0.0005476244,0.0002216544,0.0001585738,0.0001321221,0.0007012464,0.0009385825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006575808,"about_ca_system_score_gemma":0.0006364031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001197948,"about_ca_topic_score_gemma":0.0005797019,"domain_scores_codex":[0.9952546,0.0008502686,0.0002890463,0.0005011954,0.002002741,0.001102108],"domain_scores_gemma":[0.9975404,0.001434597,0.00003110546,0.0004479711,0.0003355817,0.0002103096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009589073,0.0002058732,0.0371695,0.00007917588,0.00001785754,0.000915654,0.0001814327,3.807551e-8,0.6560358,0.0002135162,0.003564508,0.3006577],"study_design_scores_gemma":[0.003390036,0.001069482,0.03744413,0.00055545,0.000004169338,0.000002864908,0.00006077903,0.00009019513,0.9543127,0.0001628419,0.002770574,0.0001367619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730462,0.00008951849,0.00003047049,0.004390757,0.0001107182,0.001169547,0.00004117785,0.00003894976,0.02108266],"genre_scores_gemma":[0.9932346,0.0009460755,0.00005803382,0.0002155425,0.0002436569,0.000126871,0.00002832575,0.0000371275,0.005109752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3005209,"threshold_uncertainty_score":0.9998393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06674329022386635,"score_gpt":0.4132207350815794,"score_spread":0.346477444857713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}