{"id":"W2260339506","doi":"10.1016/j.antiviral.2016.02.006","title":"Statins can exert dual, concentration dependent effects on HCV entry in vitro","year":2016,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Hepatitis C virus research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Pravastatin; Downregulation and upregulation; Atorvastatin; In vitro; In vivo; Pharmacology; Medicine; Statin; Ribavirin; HMG-CoA reductase; Viral entry; Reductase; Hepatitis C virus; Immunology; Cholesterol; Chemistry; Virus; Biology; Internal medicine; Enzyme; Biochemistry; Viral replication","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004327818,0.0003858281,0.0008559052,0.0003954263,0.0003752139,0.0008126136,0.0003486772,0.0004712273,0.003991948],"category_scores_gemma":[0.0006871141,0.0002847149,0.0007361794,0.0004210662,0.0002971562,0.0004489654,0.0006755599,0.0008235435,0.001403313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004225941,"about_ca_system_score_gemma":0.0009860712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002946584,"about_ca_topic_score_gemma":0.007563123,"domain_scores_codex":[0.999348,0.0001904254,0.0001199304,0.00004982685,0.0001210411,0.0001707954],"domain_scores_gemma":[0.999588,0.0001567547,0.00004434671,0.00006596093,0.00007596873,0.00006898882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005060623,0.0004528483,0.0008211989,0.0005408628,0.0001057713,0.0001491518,0.0001493905,0.0001562906,0.98264,0.0003792587,0.00143372,0.008110862],"study_design_scores_gemma":[0.0005566342,0.002872898,0.008579138,0.00005558298,0.0001504204,0.0003567473,0.0001595486,0.0008523348,0.9768934,0.0001803621,0.009305828,0.0000370225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691231,0.01488214,0.0025301,0.001141861,0.0004278949,0.0001779853,0.002676669,0.0001928754,0.008847423],"genre_scores_gemma":[0.9760876,0.007729882,0.003678655,0.0003626335,0.0001341404,0.0001486262,0.002919949,0.00005668691,0.008881845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003991948,"threshold_uncertainty_score":0.01335442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06674329022386635,"score_gpt":0.4132207350815794,"score_spread":0.346477444857713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}