{"id":"W2260384831","doi":"10.1093/molehr/gav070","title":"GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/9 expression","year":2015,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; Trophoblast; Gene knockdown; MMP2; Small interfering RNA; Placenta; Molecular biology; Endocrinology; Andrology; Cell biology; Transfection; Cell culture; Fetus; Downregulation and upregulation; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004305774,0.000234048,0.0003318953,0.0001561836,0.0002039073,0.00002255368,0.00009716664,0.0001511141,0.00003892798],"category_scores_gemma":[0.000370084,0.0002052262,0.0001141383,0.0002682711,0.0001230024,0.0001225082,0.000117888,0.0002607687,0.0001008115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000120148,"about_ca_system_score_gemma":0.00004607949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004085549,"about_ca_topic_score_gemma":0.000006167838,"domain_scores_codex":[0.998025,0.0001317415,0.0003395914,0.0007584115,0.0004605676,0.0002846612],"domain_scores_gemma":[0.9984435,0.0000124036,0.000142845,0.0009937212,0.0002260867,0.0001814097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000249836,0.0001710519,0.002184913,0.00007744724,0.00005627951,0.00009687579,0.0006730846,0.00003823317,0.9902319,0.00006125597,0.004061291,0.002097773],"study_design_scores_gemma":[0.002077459,0.0005928226,0.01726958,0.0004196673,0.0001221715,0.0002142611,0.0001803669,0.00003956174,0.9670574,0.002625929,0.009092571,0.0003081856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892981,0.003809856,0.0007766903,0.001097532,0.0004836311,0.0005718487,0.000001738951,0.0003095028,0.003651125],"genre_scores_gemma":[0.9967595,0.00005764268,0.001011587,0.0001541683,0.0004216021,0.00005615063,0.0001537338,0.00004429937,0.001341366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02317454,"threshold_uncertainty_score":0.836888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03092029399563276,"score_gpt":0.2687712831230909,"score_spread":0.2378509891274581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}