{"id":"W2260418106","doi":"","title":"Synthesis and evaluation of monomeric, dimeric and trimeric benzenesulfonamide derivatives for imaging carbonic anhydrase IX with PET","year":2014,"lang":"en","type":"article","venue":"","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Chemistry; Carbonic anhydrase; Monomer; Stereochemistry; Combinatorial chemistry; Biochemistry; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000499318,0.0003604967,0.0002543287,0.0001519003,0.0001456985,0.0002875537,0.0003966223,0.0004270909,0.0008037948],"category_scores_gemma":[0.0003439109,0.000245842,0.0001918386,0.0002262831,0.0001841004,0.0002547933,0.0001378958,0.0003867847,0.000290833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005919272,"about_ca_system_score_gemma":0.0002361518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176183,"about_ca_topic_score_gemma":0.001791973,"domain_scores_codex":[0.9998405,0.00003708343,0.00001454147,0.00002779063,0.00005213259,0.00002793316],"domain_scores_gemma":[0.9998485,0.00002025651,0.00004072252,0.00002080468,0.00003696268,0.0000327239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006896484,0.00002315739,0.00005136418,0.0000441289,0.000006940383,0.00004243083,0.000025734,0.0003936334,0.9975304,0.0001471342,0.00005366072,0.00161241],"study_design_scores_gemma":[0.00001479914,0.0002371637,0.0002419312,0.000002336113,0.0000107163,0.00009208826,0.000008272995,0.0007799771,0.9966998,0.00001161884,0.001896793,0.000004544303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753566,0.002785256,0.01797821,0.0001643114,0.00003233104,0.0002457702,0.0004224564,0.0001225863,0.002892495],"genre_scores_gemma":[0.9718736,0.001922821,0.02092018,0.00005331169,0.0000104447,0.0001093799,0.0005522361,0.00004247728,0.004515459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001176183,"threshold_uncertainty_score":0.004294813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009911125090848417,"score_gpt":0.2439509075880559,"score_spread":0.2340397824972075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}