{"id":"W2260418106","doi":"","title":"Synthesis and evaluation of monomeric, dimeric and trimeric benzenesulfonamide derivatives for imaging carbonic anhydrase IX with PET","year":2014,"lang":"en","type":"article","venue":"","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Chemistry; Carbonic anhydrase; Monomer; Stereochemistry; Combinatorial chemistry; Biochemistry; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000291507,0.00009278874,0.0001134697,0.00004092576,0.00004688094,0.00001075376,0.00002293272,0.00002100601,0.00001128729],"category_scores_gemma":[0.0001432485,0.0000756702,0.00002170081,0.00005531068,0.00007716066,0.000007687274,0.0000179588,0.00001756532,1.758556e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006141166,"about_ca_system_score_gemma":0.00003140154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002640573,"about_ca_topic_score_gemma":0.00001167557,"domain_scores_codex":[0.999427,0.0000633801,0.0001163713,0.0002164426,0.00008480776,0.00009197543],"domain_scores_gemma":[0.9996178,0.00004261846,0.00008051384,0.0001123783,0.0001157372,0.00003097619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002127626,0.00004701139,0.006261721,0.00004517136,0.00005467069,9.881431e-8,0.0000449394,0.0001576542,0.9569805,0.000211149,0.0003324687,0.03565191],"study_design_scores_gemma":[0.00190826,0.0006469723,0.0228034,0.00003350268,0.000205524,0.00002525353,0.0004003046,0.03670263,0.9346668,0.0002114431,0.002107782,0.000288108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853909,0.0005557011,0.012693,0.0001158159,0.00002484241,0.0002083233,0.000004046552,0.000007215548,0.001000134],"genre_scores_gemma":[0.9977247,0.00009395544,0.001846915,0.0001222226,0.00003600515,0.00006696896,0.00003161729,0.00001181515,0.00006576679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03654497,"threshold_uncertainty_score":0.3085741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009911125090848417,"score_gpt":0.2439509075880559,"score_spread":0.2340397824972075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}