{"id":"W2260491557","doi":"10.1038/nature16478","title":"Divergent clonal selection dominates medulloblastoma at recurrence","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":343,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University; McGill University; Canada's Michael Smith Genome Sciences Centre; BC Children's Hospital; University Health Network; University of Toronto; SickKids Foundation; BC Cancer Agency; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of British Columbia; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; Cancer Research UK; National Cancer Institute; Sparks; Canadian Institutes of Health Research; Brain Tumour Charity","keywords":"Medulloblastoma; clone (Java method); Radiation therapy; Targeted therapy; Biology; Cancer; Medicine; Oncology; Cancer research; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003506567,0.0001685767,0.0004223478,0.0009322517,0.0003931091,0.0008562025,0.0004249843,0.0004531011,0.003517813],"category_scores_gemma":[0.001052869,0.0001969092,0.0001767502,0.0004746934,0.000346129,0.0004681582,0.000469082,0.0005328714,0.000841541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005653579,"about_ca_system_score_gemma":0.0003057075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001765915,"about_ca_topic_score_gemma":0.00370735,"domain_scores_codex":[0.9996087,0.00005161753,0.00002254831,0.00008133474,0.0001191148,0.0001166546],"domain_scores_gemma":[0.9992371,0.0001388343,0.000229671,0.00009830595,0.0001003998,0.0001957122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001292703,0.0001370365,0.4817254,0.00005968641,0.00007894122,0.003320639,0.0004812067,0.0008135746,0.4642229,0.003547825,0.001313716,0.04300631],"study_design_scores_gemma":[0.00003570979,0.0004633192,0.9279773,0.00002010159,0.0001108112,0.01328666,0.0006327829,0.002705868,0.04702798,0.002723405,0.004988777,0.00002724467],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960913,0.0004909672,0.0006147553,0.00009725556,0.000007306831,0.0000073726,0.00008363581,0.00006525159,0.002542035],"genre_scores_gemma":[0.998679,0.0001325129,0.0001775207,0.00004583898,0.00001485511,0.000003904147,0.0001125969,0.0000381135,0.0007956609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003517813,"threshold_uncertainty_score":0.01176822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003575911882173322,"score_gpt":0.2316428167220798,"score_spread":0.2280669048399065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}