{"id":"W2260491557","doi":"10.1038/nature16478","title":"Divergent clonal selection dominates medulloblastoma at recurrence","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":343,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University; McGill University; Canada's Michael Smith Genome Sciences Centre; BC Children's Hospital; University Health Network; University of Toronto; SickKids Foundation; BC Cancer Agency; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of British Columbia; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; Cancer Research UK; National Cancer Institute; Sparks; Canadian Institutes of Health Research; Brain Tumour Charity","keywords":"Medulloblastoma; clone (Java method); Radiation therapy; Targeted therapy; Biology; Cancer; Medicine; Oncology; Cancer research; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005689568,0.00009514828,0.00006456541,0.00001826577,0.00006889242,0.000008457414,0.0001109823,0.0005232287,0.0001355011],"category_scores_gemma":[0.0001494261,0.00006794244,0.00005570864,0.00004392086,0.00003683221,0.000001827882,0.0001189055,0.000172639,0.00004607712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005447524,"about_ca_system_score_gemma":0.0000474723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004039696,"about_ca_topic_score_gemma":0.00009386458,"domain_scores_codex":[0.9993992,0.00001399745,0.0000812069,0.0002479711,0.00009814773,0.0001594841],"domain_scores_gemma":[0.9996542,0.00002163132,0.00004219716,0.0001332456,0.00008496614,0.00006381015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002095982,0.00003425628,0.01449655,0.000006588331,0.00003110327,0.000002432278,0.00001164478,0.000006377898,0.8590955,0.0004875477,0.110439,0.01517938],"study_design_scores_gemma":[0.0004175459,0.0001547602,0.01045882,0.00001487603,0.000009425141,0.0000181293,0.000002714818,0.000006240106,0.5469295,0.000187166,0.4416631,0.0001377056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947861,0.002490653,0.000244898,0.0009057595,0.0007068897,0.00008419716,0.00009002709,0.000009967944,0.0006814989],"genre_scores_gemma":[0.9959546,0.0009845786,0.0002517384,0.0004920278,0.0004372586,0.00001132396,0.00003862155,0.00001078496,0.00181908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.331224,"threshold_uncertainty_score":0.4035619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003575911882173322,"score_gpt":0.2316428167220798,"score_spread":0.2280669048399065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}