{"id":"W2260494368","doi":"10.1016/j.bbcan.2016.04.001","title":"Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles, and potential","year":2016,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research; Fondation du cancer du sein du Québec","keywords":"Epigenetics; Biology; Gene silencing; Reprogramming; DNA methylation; Suppressor; Genetics; Gene; Transcription factor; Tumor suppressor gene; Computational biology; Cancer research; Carcinogenesis; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006596099,0.000642121,0.0008573245,0.001195407,0.0003171119,0.0008821603,0.0009427897,0.001040691,0.001869195],"category_scores_gemma":[0.0005546025,0.0001984826,0.000295068,0.001244761,0.001218348,0.001582405,0.0007651618,0.002133742,0.001150031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009626225,"about_ca_system_score_gemma":0.0009806397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008281742,"about_ca_topic_score_gemma":0.00144368,"domain_scores_codex":[0.999837,0.00003120098,0.0000160455,0.0000332876,0.00006172094,0.00002055883],"domain_scores_gemma":[0.99978,0.0001003689,0.00002348651,0.00001159054,0.00005449177,0.00003006611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000694448,0.00004490343,0.000226538,0.008401412,0.00005935404,0.0002922168,0.0001378448,0.0005009915,0.00640741,0.0251765,0.0359652,0.9227182],"study_design_scores_gemma":[0.000008032742,0.00005109509,0.0004447726,0.001041211,0.00003287446,0.000983783,0.00007564324,0.00008994413,0.001240862,0.00681678,0.9891989,0.00001619908],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001122926,0.9980995,0.0002210702,0.0005694597,0.0001878531,0.000001684321,0.000008213763,0.000007418287,0.0007925751],"genre_scores_gemma":[0.001010957,0.9977064,0.0002030243,0.0002565076,0.0002007226,0.000004612977,0.0000168549,0.000002109998,0.000598739],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001869195,"threshold_uncertainty_score":0.006984413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03587431352780069,"score_gpt":0.3392785417355682,"score_spread":0.3034042282077675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}