{"id":"W2260592789","doi":"10.7554/elife.11815","title":"Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4","year":2016,"lang":"en","type":"article","venue":"eLife","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Stoichiometry; Chemistry; Conductance; Protein subunit; Amino acid; Repolarization; Biophysics; Ion channel; Potassium channel; Stereochemistry; Biochemistry; Electrophysiology; Biology; Neuroscience; Physics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001669417,0.0001477685,0.0004336876,0.0001198259,0.00008556101,0.000003554619,0.0001467306,0.0001124349,0.00007700043],"category_scores_gemma":[0.0002092344,0.00008017859,0.0002346254,0.0004053614,0.0002634937,0.00003784349,0.0001047566,0.0001816292,0.00002558922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000322482,"about_ca_system_score_gemma":0.00009929867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001820829,"about_ca_topic_score_gemma":0.000007026119,"domain_scores_codex":[0.9988687,0.00005966561,0.0003002108,0.0002128939,0.0002677204,0.0002908217],"domain_scores_gemma":[0.9991099,0.0001175474,0.0001438559,0.0003767012,0.0001618819,0.00009009256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003120529,0.0000318103,0.005483627,0.00004241386,0.0001138402,0.000009129662,0.0003448317,0.000004456273,0.9896101,0.00022239,0.001222869,0.002602442],"study_design_scores_gemma":[0.001086118,0.0002790838,0.2401835,0.0002526083,0.00006118169,0.00008264944,0.0001181284,0.00002560025,0.7571117,0.0001305746,0.0005529112,0.000115918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969366,0.0004199584,0.0001721064,0.00122161,0.0003948951,0.0002831343,0.00004042952,0.0000268076,0.0005044448],"genre_scores_gemma":[0.9980342,0.00003360382,0.0001714439,0.0009759949,0.0002728967,0.000009827287,0.000005468135,0.00001591234,0.0004807012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2346999,"threshold_uncertainty_score":0.3269588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01979658451908667,"score_gpt":0.2791757933821722,"score_spread":0.2593792088630856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}