{"id":"W2260639798","doi":"10.1096/fasebj.22.1_supplement.645.18","title":"Intracellular HIV‐Nef Downregulates LPS‐induced IL‐12p40 Expression by Inhibiting JNK‐activated NFkB in Human Monocytic Cells","year":2008,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Intracellular; Cell biology; NF-κB; Biology; Downregulation and upregulation; Signal transduction; Immune system; Chemistry; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000138002,0.0003258935,0.0002655223,0.000197675,0.0001492022,0.0002708645,0.0001315212,0.0001993659,0.0009202457],"category_scores_gemma":[0.0001060091,0.0001336936,0.0002408419,0.0001071267,0.0001855296,0.0001078437,0.0001117734,0.000550391,0.0003545401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002903939,"about_ca_system_score_gemma":0.0003101229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001852994,"about_ca_topic_score_gemma":0.002281449,"domain_scores_codex":[0.9998986,0.00001520002,0.00001234789,0.00001325339,0.00002665733,0.00003390471],"domain_scores_gemma":[0.9999421,0.00001551384,0.00001001948,0.000009520601,0.000008057822,0.00001476108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001686882,0.00006820327,0.00008678307,0.00003190324,0.000002559124,0.00004740301,0.00002160822,0.00003580437,0.9985492,0.00003962457,0.00003270709,0.0009156697],"study_design_scores_gemma":[0.00007151315,0.000756102,0.004012603,0.00000954159,0.00001922395,0.0002171942,0.00002630526,0.0009762192,0.9914144,0.00003044679,0.002461739,0.000004625144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939834,0.002387308,0.001626425,0.00009815639,0.0000464825,0.00004317458,0.0004362024,0.0000648513,0.001314104],"genre_scores_gemma":[0.9911804,0.001687112,0.00336096,0.0000682823,0.00002335127,0.00007703669,0.000702107,0.00001663137,0.002884059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001852994,"threshold_uncertainty_score":0.003684402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02189666835576005,"score_gpt":0.2486559442907955,"score_spread":0.2267592759350355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}