{"id":"W2261058162","doi":"10.1016/j.molbiopara.2016.02.003","title":"Inactivation of the cytosolic and mitochondrial serine hydroxymethyl transferase genes in Leishmania major","year":2015,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Biology; Serine; Serine hydroxymethyltransferase; Biochemistry; Leishmania; Trypanosoma cruzi; Gene; Trypanosoma brucei; Leishmania major; Mutant; Cytosol; Transferase; Enzyme; Trypanosoma; Molecular biology; Genetics; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001423302,0.0003866916,0.0001512123,0.0002415359,0.0001045303,0.0001787124,0.000257984,0.0002551942,0.001444369],"category_scores_gemma":[0.0001336584,0.0001440364,0.0002430898,0.0001427665,0.0003047423,0.0001302167,0.0001481965,0.0004881607,0.000257456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000239975,"about_ca_system_score_gemma":0.0002443793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004444221,"about_ca_topic_score_gemma":0.0006303161,"domain_scores_codex":[0.9998928,0.00002160408,0.00001071846,0.00002159419,0.00002539552,0.00002783139],"domain_scores_gemma":[0.9998835,0.00002341827,0.00004570488,0.00001554737,0.00001118648,0.00002065408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001622815,0.0000293944,0.0001074811,0.00002509146,0.000004064556,0.00003692183,0.00001123624,0.00004825411,0.998149,0.0002536374,0.0000214625,0.001151119],"study_design_scores_gemma":[0.00005482863,0.00042916,0.002852596,0.000007314619,0.00004681854,0.0003637006,0.00004043272,0.000984078,0.9929984,0.0001603371,0.002056269,0.000006150604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946977,0.0006318662,0.003451498,0.0001325817,0.00003533007,0.00002192019,0.0001939753,0.00008948372,0.0007456811],"genre_scores_gemma":[0.9961272,0.0003854869,0.0009609407,0.0000388497,0.000008080259,0.0000161683,0.000308178,0.00002387806,0.002131211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001444369,"threshold_uncertainty_score":0.00483191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01949376455369897,"score_gpt":0.3077858876152193,"score_spread":0.2882921230615203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}