{"id":"W2261890086","doi":"10.1093/hmg/ddv483","title":"Urogenital development in Pallister–Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor","year":2015,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Biology; Ureteric bud; Kidney development; Morphogenesis; Intermediate mesoderm; Bone morphogenetic protein 4; GLI3; Mesonephric duct; Cell biology; Mesenchyme; Endocrinology; Kidney; Internal medicine; Pathology; Genetics; Cellular differentiation; Gastrulation; Embryo; Repressor; Gene expression; Embryogenesis; Embryonic stem cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007049136,0.0003912012,0.0001705593,0.000281471,0.0001331987,0.0001553109,0.0001786109,0.0002858638,0.001983503],"category_scores_gemma":[0.0001190307,0.000180798,0.0003029549,0.000106895,0.000419409,0.0001409738,0.00032214,0.0005123966,0.0003947684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001787124,"about_ca_system_score_gemma":0.0001940412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006582095,"about_ca_topic_score_gemma":0.001300647,"domain_scores_codex":[0.9999033,0.00001156038,0.000008296871,0.00002561584,0.00003556836,0.00001567132],"domain_scores_gemma":[0.9999334,0.000009534438,0.00002423936,0.00000746697,0.000003207528,0.00002217373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007358973,0.000009287097,0.001752262,0.00004879116,0.00001599023,0.001259673,0.00004225113,0.00009853763,0.993573,0.0002323088,0.00008753335,0.002806918],"study_design_scores_gemma":[0.00006636218,0.0002597709,0.08939904,0.00003221131,0.0001117329,0.02785401,0.0001081633,0.001930358,0.8688715,0.0003905622,0.01095676,0.00001943612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940275,0.0008342119,0.002834653,0.0001421717,0.00001930792,0.000009673124,0.0003429687,0.0002174019,0.001572092],"genre_scores_gemma":[0.9949916,0.000576809,0.001791981,0.00006679775,0.000006562217,0.00001377025,0.0002905045,0.00004561323,0.002216335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001983503,"threshold_uncertainty_score":0.006635427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01703984973510449,"score_gpt":0.2512509074855257,"score_spread":0.2342110577504212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}