{"id":"W2261890086","doi":"10.1093/hmg/ddv483","title":"Urogenital development in Pallister–Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor","year":2015,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Biology; Ureteric bud; Kidney development; Morphogenesis; Intermediate mesoderm; Bone morphogenetic protein 4; GLI3; Mesonephric duct; Cell biology; Mesenchyme; Endocrinology; Kidney; Internal medicine; Pathology; Genetics; Cellular differentiation; Gastrulation; Embryo; Repressor; Gene expression; Embryogenesis; Embryonic stem cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382887,0.0002409557,0.0002554895,0.000101559,0.00003305863,0.00001676899,0.0002611636,0.0002706312,0.00001449971],"category_scores_gemma":[0.00001121434,0.0002311541,0.00008116209,0.0001489563,0.0001642444,0.000003139254,0.0001823195,0.0001691599,0.000007805798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005623871,"about_ca_system_score_gemma":0.0001279208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002124523,"about_ca_topic_score_gemma":0.0000191574,"domain_scores_codex":[0.9983293,0.00009088519,0.0005039446,0.0005055609,0.0002638388,0.0003064664],"domain_scores_gemma":[0.9992195,0.000004378851,0.0001464854,0.0003926977,0.00009612549,0.0001407486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009420172,0.0001967969,0.002168902,0.00003209654,0.00002925186,0.0002248647,0.0005307019,0.001084902,0.9946212,0.00001846374,0.0008136543,0.0001849297],"study_design_scores_gemma":[0.001759846,0.0002167056,0.00147862,0.00009189738,0.00001202471,0.00002788872,0.0001285635,0.00003471684,0.9859951,0.00004212126,0.009895863,0.0003166475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883158,0.009088936,0.0005771177,0.00001446366,0.00007350402,0.0002942199,0.00002453597,0.000005641539,0.001605805],"genre_scores_gemma":[0.9978821,0.0002909378,0.001166712,0.00009095392,0.00001584618,0.0000344842,0.0001739321,0.000031698,0.0003133034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009566357,"threshold_uncertainty_score":0.9426189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01703984973510449,"score_gpt":0.2512509074855257,"score_spread":0.2342110577504212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}