{"id":"W2262238013","doi":"","title":"AQ4N, a prodrug activated under hypoxic conditions results in complementary drug distribution and increased therapeutic activity when administered with mitoxantrone or doxorubicin in solid tumors","year":2007,"lang":"en","type":"article","venue":"","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Mitoxantrone; Doxorubicin; Prodrug; Pharmacology; Topoisomerase; Distribution (mathematics); In vivo; Cancer research; Chemistry; Biology; Chemotherapy; Medicine; In vitro; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001683573,0.0002840249,0.000185426,0.0002556191,0.0000837378,0.0001090426,0.0001342127,0.000215477,0.001735647],"category_scores_gemma":[0.0001072291,0.0001140147,0.0001703982,0.00009708939,0.0001768766,0.0002327976,0.0001201054,0.0001899612,0.0002024929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002265577,"about_ca_system_score_gemma":0.0001317469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002915029,"about_ca_topic_score_gemma":0.0003441408,"domain_scores_codex":[0.9999186,0.0000169541,0.00000711861,0.00002202453,0.00001964842,0.00001559536],"domain_scores_gemma":[0.999939,0.00001147384,0.00002556036,0.000005823639,0.00000700571,0.00001115671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001735832,0.00003751821,0.0001208273,0.00002754158,0.000003162921,0.00002444099,0.000004212221,0.00006778449,0.9975762,0.00004599204,0.00002986034,0.001888741],"study_design_scores_gemma":[0.00004285471,0.001480193,0.001463577,0.000002898134,0.0000105582,0.0002132285,0.000005049709,0.0005933161,0.9947407,0.00002124586,0.001424056,0.000002458892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944611,0.0006376354,0.003098386,0.00004105881,0.00002333509,0.00005344257,0.0001674473,0.00007989674,0.001437764],"genre_scores_gemma":[0.9909461,0.0004128973,0.005506597,0.00003622999,0.00001033024,0.00006002771,0.0003865686,0.00001197572,0.002629343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001735647,"threshold_uncertainty_score":0.005806327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172883761661258,"score_gpt":0.2869756163409436,"score_spread":0.2696872401748178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}