{"id":"W2262255889","doi":"10.1073/pnas.1522067113","title":"<i>Legionella pneumophila</i> S1P-lyase targets host sphingolipid metabolism and restrains autophagy","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biological and Environmental Research; National Institute of General Medical Sciences; Bundesministerium für Bildung und Forschung; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; U.S. Department of Energy; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agence Nationale de la Recherche; National Institutes of Health; Generalitat de Catalunya; National Science Foundation","keywords":"Legionella pneumophila; Sphingolipid; Autophagy; Host (biology); Microbiology; Biology; Cell biology; Biochemistry; Bacteria; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008009777,0.0001002254,0.0001272138,0.00008785503,0.0001719201,0.00001949783,0.0005579429,0.0001026325,0.000002779879],"category_scores_gemma":[0.000450313,0.00005513525,0.00006859799,0.0002486809,0.001179735,0.00003335437,0.0002577249,0.00008260222,0.000001160103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007828979,"about_ca_system_score_gemma":0.00005130891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005782034,"about_ca_topic_score_gemma":1.063981e-7,"domain_scores_codex":[0.9986266,0.000008311685,0.0002210324,0.0003060251,0.000638488,0.0001995768],"domain_scores_gemma":[0.9994785,0.00003656663,0.0002008997,0.00001383347,0.0002049903,0.00006518095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001949103,0.00002382382,0.001272225,0.0000214103,0.00001216685,1.327782e-8,0.00003032182,0.000001269213,0.9877889,0.009376277,0.001207464,0.0002466127],"study_design_scores_gemma":[0.0002946313,0.00005072357,0.04237331,0.00004553909,0.000006600322,0.00001686767,0.00003530612,0.00002053759,0.9448504,0.007961418,0.004255455,0.00008924102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890921,0.0007119654,0.000001455155,0.007520006,0.00002471,0.0001208926,0.00002278248,0.000004763465,0.00250132],"genre_scores_gemma":[0.9980322,0.000584909,0.0002416307,0.0003794284,0.0002453099,0.000006529146,1.711679e-7,0.000005530253,0.0005043162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04293855,"threshold_uncertainty_score":0.4346783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02627394834692337,"score_gpt":0.2931107422981393,"score_spread":0.2668367939512159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}