{"id":"W2262255889","doi":"10.1073/pnas.1522067113","title":"<i>Legionella pneumophila</i> S1P-lyase targets host sphingolipid metabolism and restrains autophagy","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biological and Environmental Research; National Institute of General Medical Sciences; Bundesministerium für Bildung und Forschung; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; U.S. Department of Energy; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agence Nationale de la Recherche; National Institutes of Health; Generalitat de Catalunya; National Science Foundation","keywords":"Legionella pneumophila; Sphingolipid; Autophagy; Host (biology); Microbiology; Biology; Cell biology; Biochemistry; Bacteria; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009990087,0.0003408782,0.0001492589,0.0001606074,0.0001471253,0.0004303562,0.0001092346,0.0002513705,0.002466088],"category_scores_gemma":[0.00008280478,0.00007488371,0.0001861954,0.0001046089,0.0002402415,0.0001203787,0.0001862743,0.0002722309,0.001234933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004592689,"about_ca_system_score_gemma":0.0001782293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007359238,"about_ca_topic_score_gemma":0.0009364242,"domain_scores_codex":[0.9999161,0.00001786189,0.00000664138,0.00001526717,0.00002317272,0.00002098209],"domain_scores_gemma":[0.9999497,0.000005830749,0.00001507554,0.000006189988,0.000006805521,0.000016482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000126217,0.00001647564,0.0003766746,0.00004445981,0.000004171838,0.00009138582,0.000008460786,0.00005454025,0.9964308,0.0001492327,0.0003466533,0.002350919],"study_design_scores_gemma":[0.00001649878,0.000180009,0.01230126,0.0000138276,0.00001118002,0.000502544,0.00004408359,0.0009024406,0.9719155,0.0001281806,0.01397877,0.000005680088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974702,0.00672164,0.002882838,0.001041221,0.0001409965,0.00003186282,0.0007752987,0.0004712548,0.01323296],"genre_scores_gemma":[0.9822978,0.002340862,0.001383745,0.0001963942,0.00003967123,0.00001991975,0.0008659042,0.00004412711,0.01281145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002466088,"threshold_uncertainty_score":0.008249879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02627394834692337,"score_gpt":0.2931107422981393,"score_spread":0.2668367939512159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}