{"id":"W2262279506","doi":"10.1016/s0140-6736(16)00143-4","title":"Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study","year":2016,"lang":"en","type":"article","venue":"The Lancet","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":400,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; McGill University; Douglas Mental Health University Institute; McGill University Health Centre; University of Toronto; Dalhousie University; Montreal Neurological Institute and Hospital","funders":"National Institute of Mental Health; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; Eli Lilly Japan; National Institutes of Health; Rheinische Friedrich-Wilhelms-Universität Bonn; Centro de Investigación Biomédica en Red de Salud Mental; Alfried Krupp von Bohlen und Halbach-Stiftung; Eli Lilly and Company; Lundbeckfonden; Bundesministerium für Bildung und Forschung; University of Oxford; University of New South Wales; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Fondation FondaMental; Broad Institute; J. Willard and Alice S. Marriott Foundation; National Cancer Institute; Servier; Gilead Sciences; Virginia Commonwealth University; National Institute on Drug Abuse; Stanley Center for Psychiatric Research, Broad Institute; Novo Nordisk; University of Pennsylvania; Deutsche Forschungsgemeinschaft; University of Louisville; GlaxoSmithKline; Orexigen Therapeutics; Johns Hopkins University; Dainippon Sumitomo Pharma; Ministry of Education, India; Pfizer; Rush University; Wayne State University; H. Lundbeck A/S; Sunovion; National Science Foundation","keywords":"Genome-wide association study; Bipolar disorder; Genetic association; Lithium (medication); Association (psychology); Genetics; Medicine; Biology; Computational biology; Psychiatry; Single-nucleotide polymorphism; Psychology; Genotype; Gene; Psychotherapist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007466826,0.0006653049,0.0007372852,0.0007083431,0.0006631413,0.0009325769,0.0007247181,0.001538124,0.002136486],"category_scores_gemma":[0.001836617,0.0005600437,0.001597003,0.001951349,0.0005052169,0.0003425605,0.0005056799,0.001247134,0.0001854703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003905087,"about_ca_system_score_gemma":0.0003374277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01322743,"about_ca_topic_score_gemma":0.01835264,"domain_scores_codex":[0.9991384,0.0002529697,0.000110467,0.0002693874,0.0001205583,0.0001083135],"domain_scores_gemma":[0.9987972,0.0004303496,0.0004481686,0.0001016845,0.00009030877,0.0001323746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004822167,0.0002281232,0.9690142,0.0001697286,0.006708232,0.001445346,0.0003541675,0.000326594,0.01015176,0.0002002516,0.001103144,0.005476248],"study_design_scores_gemma":[0.0001849971,0.0001361668,0.9964708,0.00002044936,0.001841858,0.0004220135,0.0001253669,0.0003096819,0.0001287569,0.0001023165,0.0002420391,0.00001556239],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967527,0.001608935,0.0001563617,0.000346781,0.00003457144,0.000008387412,0.0005650106,0.00001282768,0.0005144368],"genre_scores_gemma":[0.9987602,0.000359136,0.0002027677,0.0001388606,0.00003569866,0.000007411229,0.0002862356,0.000007956262,0.0002017158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01322743,"threshold_uncertainty_score":0.02630091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734996290779544,"score_gpt":0.2626473832048953,"score_spread":0.2452974202970999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}