{"id":"W2262913519","doi":"10.1093/jac/dkv211","title":"Induced tigecycline resistance in<i>Streptococcus pneumoniae</i>mutants reveals mutations in ribosomal proteins and rRNA","year":2015,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Tigecycline; Biology; Microbiology; Mutant; Efflux; Ribosomal RNA; Streptococcus pneumoniae; Tetracycline; Genetics; Gene; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101571,0.0005640034,0.0003296765,0.0002979133,0.0001469026,0.0003212595,0.0002623438,0.0003590476,0.001146448],"category_scores_gemma":[0.0002725111,0.0001906533,0.0004761819,0.0002327394,0.0002042187,0.0001139585,0.0002871329,0.0005989107,0.0005347476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003767776,"about_ca_system_score_gemma":0.000308548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001911314,"about_ca_topic_score_gemma":0.002078479,"domain_scores_codex":[0.999726,0.0000352777,0.00004240128,0.00004952344,0.00008764717,0.00005921078],"domain_scores_gemma":[0.9997203,0.00005006269,0.0001132244,0.00003716464,0.00003580273,0.00004349895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005468661,0.00002375604,0.0004745637,0.00002086705,0.000007512804,0.00005785363,0.00001380698,0.00004408371,0.9986589,0.00002173143,0.00001856273,0.0006037632],"study_design_scores_gemma":[0.000008889842,0.0002975326,0.01473818,0.00001160687,0.00003063893,0.0008038983,0.00005669602,0.000774628,0.9821528,0.00001973208,0.001095977,0.000009504703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966182,0.000240442,0.001728274,0.00005172685,0.00001753277,0.00003507742,0.0005625364,0.00008184606,0.0006644133],"genre_scores_gemma":[0.9937468,0.0002127624,0.003439585,0.0000423197,0.000007328262,0.00004717589,0.001031363,0.00007548189,0.001397134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001911314,"threshold_uncertainty_score":0.003835201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561635422804262,"score_gpt":0.2726105162487075,"score_spread":0.2569941620206649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}