{"id":"W2262971706","doi":"10.1186/s13550-016-0170-2","title":"Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors","year":2016,"lang":"en","type":"article","venue":"EJNMMI Research","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Education, Culture, Sports, Science and Technology; Institut national de la recherche scientifique","keywords":"Radioligand; Ex vivo; In vivo; Positron emission tomography; Histamine H3 receptor; Receptor; Preclinical imaging; Medicine; Ligand (biochemistry); Biodistribution; Nuclear medicine; Radioligand Assay; Pharmacology; Antagonist; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001266288,0.000232278,0.000448442,0.0003230634,0.0003593244,0.00001400316,0.0004412165,0.0001795225,0.002121105],"category_scores_gemma":[0.0006720258,0.0001643315,0.0001116723,0.0002934471,0.0007620841,0.00008498335,0.0002196112,0.0002837207,0.0003514845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002660569,"about_ca_system_score_gemma":0.0005246019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009546681,"about_ca_topic_score_gemma":0.0001194647,"domain_scores_codex":[0.9974844,0.0001779041,0.0005078326,0.0005137434,0.0001828619,0.001133185],"domain_scores_gemma":[0.9982038,0.0007292812,0.0001479781,0.0003815193,0.0004325171,0.0001049694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006995434,0.0003983361,0.0002760765,0.00009708217,0.000213082,0.000005899935,0.002330211,3.400682e-7,0.9591296,0.003268341,0.0127889,0.02079259],"study_design_scores_gemma":[0.002908018,0.000377537,0.0009650328,0.0001070597,0.00000960839,0.00002584861,0.0004210916,0.000001776046,0.4895684,0.0001095471,0.5053234,0.0001826946],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877899,0.001394559,0.004860688,0.0009414056,0.0006005711,0.001041999,0.0002174518,0.00004743143,0.003106039],"genre_scores_gemma":[0.9489641,0.0001697112,0.00402174,0.00002996581,0.00009664887,0.0001755632,0.0001878113,0.000043186,0.04631134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4925345,"threshold_uncertainty_score":0.9987911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05632199263333496,"score_gpt":0.324183762770057,"score_spread":0.2678617701367221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}