{"id":"W2262974530","doi":"10.1186/s13058-016-0676-6","title":"Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer","year":2016,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Ontario Ministry of Research and Innovation; Ontario Institute for Cancer Research","keywords":"Epirubicin; Anthracycline; Cancer research; Histone deacetylase; Breast cancer; Medicine; Histone; Biology; Cancer; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009590074,0.0002163051,0.0001754148,0.0002928801,0.0001065935,0.0001791232,0.0001050088,0.0001531163,0.001607571],"category_scores_gemma":[0.00008340563,0.0001055186,0.0001371766,0.0002641409,0.0001299799,0.00008272735,0.0001072324,0.0002832216,0.0003411479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000207873,"about_ca_system_score_gemma":0.0001130356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003940918,"about_ca_topic_score_gemma":0.0007551275,"domain_scores_codex":[0.9999254,0.000007768447,0.000006456417,0.00002169637,0.00002231916,0.00001647613],"domain_scores_gemma":[0.9999027,0.000009861872,0.00004442367,0.000006901413,0.00001403877,0.00002192691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001703692,0.00002769288,0.004377154,0.00006322408,0.00001605006,0.00006119956,0.00001279077,0.00003849027,0.993212,0.00002058729,0.00005000936,0.001950344],"study_design_scores_gemma":[0.00004540264,0.0009391864,0.385831,0.00002021281,0.0001075989,0.002261403,0.00009907981,0.0008037946,0.6050071,0.0001109529,0.004765433,0.000008839742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940662,0.003264914,0.001211014,0.00006016983,0.000008922276,0.00002328422,0.0006378778,0.00004852307,0.0006791618],"genre_scores_gemma":[0.9949027,0.001498881,0.0007870249,0.0000430304,0.000006952202,0.00003354309,0.00135817,0.000009585176,0.001360151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001607571,"threshold_uncertainty_score":0.005377829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0259473345739484,"score_gpt":0.3643308900053718,"score_spread":0.3383835554314235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}