{"id":"W2263029921","doi":"10.1371/journal.pone.0140157","title":"Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Université Laval; New York State Stem Cell Science; Northwestern University","keywords":"Signal transducing adaptor protein; Ubiquitin ligase; Ubiquitin; Cell biology; Intermediate filament; Phenotype; Heat shock protein; DNA ligase; Biology; Neurofilament; Chemistry; Genetics; Cytoskeleton; Signal transduction; Gene; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007094231,0.0002628541,0.0002659188,0.0003431456,0.000194029,0.000185254,0.0001606455,0.0003414674,0.001191081],"category_scores_gemma":[0.0001650233,0.0001516833,0.0002890393,0.0002380512,0.000154666,0.0001553296,0.0002777822,0.0002675121,0.0003363002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002041303,"about_ca_system_score_gemma":0.00006262725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005795822,"about_ca_topic_score_gemma":0.0008762055,"domain_scores_codex":[0.9999121,0.00001056345,0.000008409442,0.0000248795,0.00001970096,0.0000242283],"domain_scores_gemma":[0.999893,0.00001439169,0.00003676429,0.00000687682,0.000009185701,0.00003984413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005771227,0.00004496904,0.02272166,0.00006041944,0.00007438242,0.002693499,0.00006646843,0.0001026107,0.9716585,0.00005930809,0.0001515249,0.001789579],"study_design_scores_gemma":[0.00005519448,0.0003134998,0.7281179,0.00002097393,0.0001842443,0.02053685,0.0002530142,0.001798609,0.246585,0.0002407706,0.001869105,0.00002483006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993107,0.0002010977,0.0001853938,0.00002277192,0.000003290526,0.000002210849,0.00008020242,0.000008568052,0.0001856566],"genre_scores_gemma":[0.9990348,0.00009140584,0.000266471,0.00004329908,0.000002063594,0.000003054772,0.0002218398,0.000004611236,0.0003326893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191081,"threshold_uncertainty_score":0.003984571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03160524281462715,"score_gpt":0.2395229926639582,"score_spread":0.2079177498493311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}