{"id":"W2263144298","doi":"10.1111/ijd.13236","title":"Secukinumab improves patient‐reported psoriasis symptoms of itching, pain, and scaling: results of two phase 3, randomized, placebo‐controlled clinical trials","year":2016,"lang":"en","type":"article","venue":"International Journal of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health; Probity Medical Research","funders":"Novartis Pharmaceuticals Corporation; Pfizer; Tufts Medical Center; Eli Lilly and Company; Amgen","keywords":"Medicine; Secukinumab; Itching; Placebo; Dermatology; Randomized controlled trial; Psoriasis; Clinical trial; Physical therapy; Alternative medicine; Surgery; Internal medicine; Psoriatic arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.004612314,0.0002301729,0.002498239,0.0004135106,0.00003859496,0.000009942733,0.0003152052,0.0002937741,0.00007785289],"category_scores_gemma":[0.01461795,0.0001310933,0.0009051769,0.00005715175,0.0004696648,0.0001404821,0.00007349502,0.0001735706,0.000004355305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002768798,"about_ca_system_score_gemma":0.0002149813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000220182,"about_ca_topic_score_gemma":0.000004771085,"domain_scores_codex":[0.9897177,0.005064598,0.004612516,0.0002397186,0.000155295,0.0002102084],"domain_scores_gemma":[0.9806059,0.01282815,0.005490382,0.0001853539,0.0008344165,0.00005581692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5719035,0.000991894,0.003323339,0.00001304253,0.0131829,0.0003168126,0.0005550447,0.00000121875,0.0676918,0.000887421,0.0005786639,0.3405543],"study_design_scores_gemma":[0.9120853,0.0009528455,0.0002083839,0.0002366656,0.001438209,0.004818683,0.0001281653,0.00002886924,0.07701754,0.001529563,0.001387141,0.0001686215],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901612,0.002731749,0.00163074,0.001431351,0.003305043,0.0004591678,0.00009776503,0.00001147414,0.000171522],"genre_scores_gemma":[0.9988393,0.0005579807,0.0002637458,0.000065897,0.0001373435,0.00001629659,0.00002156233,0.00001305867,0.00008486954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3403857,"threshold_uncertainty_score":0.9936823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0335983227720286,"score_gpt":0.357845622776289,"score_spread":0.3242473000042603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}