{"id":"W2263144298","doi":"10.1111/ijd.13236","title":"Secukinumab improves patient‐reported psoriasis symptoms of itching, pain, and scaling: results of two phase 3, randomized, placebo‐controlled clinical trials","year":2016,"lang":"en","type":"article","venue":"International Journal of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health; Probity Medical Research","funders":"Novartis Pharmaceuticals Corporation; Pfizer; Tufts Medical Center; Eli Lilly and Company; Amgen","keywords":"Medicine; Secukinumab; Itching; Placebo; Dermatology; Randomized controlled trial; Psoriasis; Clinical trial; Physical therapy; Alternative medicine; Surgery; Internal medicine; Psoriatic arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006643891,0.001348315,0.003243399,0.0004765895,0.0004981388,0.001073367,0.0008630928,0.001732165,0.004309097],"category_scores_gemma":[0.005174369,0.0006381335,0.003117856,0.000725624,0.000995439,0.0009376522,0.0003298337,0.001895705,0.0005238291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000639558,"about_ca_system_score_gemma":0.001084509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005757193,"about_ca_topic_score_gemma":0.001424415,"domain_scores_codex":[0.997612,0.001368561,0.0002920649,0.0002480361,0.0003019254,0.0001774248],"domain_scores_gemma":[0.9967148,0.001286033,0.0009894114,0.0002680305,0.0003299949,0.0004117968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9013928,0.01305283,0.002025298,0.003279943,0.006592095,0.0000613676,0.0001697076,0.0005761116,0.007860613,0.0001177695,0.001662642,0.06320891],"study_design_scores_gemma":[0.9224277,0.06615321,0.006916788,0.0001411335,0.002157847,0.00007117682,0.00002703753,0.0002580413,0.0008231273,0.00009561224,0.0009014996,0.00002671211],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9533389,0.03385686,0.001801208,0.001023926,0.0006530028,0.004921944,0.001720792,0.0002584468,0.002424913],"genre_scores_gemma":[0.9701727,0.01779607,0.002337132,0.001489955,0.0006814361,0.005008094,0.001391726,0.0000518887,0.001070995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006643891,"threshold_uncertainty_score":0.0351367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0335983227720286,"score_gpt":0.357845622776289,"score_spread":0.3242473000042603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}