{"id":"W2263156370","doi":"10.1104/pp.15.01813","title":"A Picrinine <i>N</i>-Methyltransferase Belongs to a New Family of γ-Tocopherol-Like Methyltransferases Found in Medicinal Plants That Make Biologically Active Monoterpenoid Indole Alkaloids","year":2016,"lang":"en","type":"article","venue":"PLANT PHYSIOLOGY","topic":"Traditional and Medicinal Uses of Annonaceae","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"","keywords":"Catharanthus roseus; Apocynaceae; Biology; Methyltransferase; Vindoline; O-methyltransferase; Secondary metabolite; Biochemistry; Gene family; Botany; Tocopherol; Indole alkaloid; Gene; Indole test; Genetics; Gene expression; Vitamin E; Methylation; Vinblastine; Antioxidant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001611614,0.000335161,0.0005725161,0.0001439849,0.00003957352,0.000004215292,0.0003727008,0.0002478883,0.00005960188],"category_scores_gemma":[0.00007792744,0.0002194073,0.0001211347,0.000141618,0.0002245879,0.00001120574,0.00006982914,0.0001556472,0.00001824072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002450323,"about_ca_system_score_gemma":0.0002300846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005474475,"about_ca_topic_score_gemma":0.0003984764,"domain_scores_codex":[0.998081,0.0001451831,0.0004082708,0.0006444176,0.0002150803,0.0005061],"domain_scores_gemma":[0.9990731,0.0002285481,0.0000833364,0.0002701723,0.00006583433,0.0002790414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005498967,0.0002191149,0.0007186665,0.00002785661,0.000113354,0.00003943031,0.0001460783,0.00002215053,0.9787906,0.00007914959,0.001088779,0.0132559],"study_design_scores_gemma":[0.006066541,0.006259319,0.2314989,0.0003862101,0.0000516541,0.0001340778,0.0002533072,0.000002141522,0.7320565,0.001574694,0.02109405,0.0006225972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950367,0.0005818252,0.001872028,0.000748212,0.0002428416,0.0004712534,0.000842263,0.0000189586,0.0001859311],"genre_scores_gemma":[0.9951469,0.0008646169,0.0006156127,0.0024018,0.0003239094,0.000077541,0.0004127323,0.00002232964,0.0001345181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2467341,"threshold_uncertainty_score":0.8947169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220932974302598,"score_gpt":0.2510838522021892,"score_spread":0.2288745224591632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}