{"id":"W2263156370","doi":"10.1104/pp.15.01813","title":"A Picrinine <i>N</i>-Methyltransferase Belongs to a New Family of γ-Tocopherol-Like Methyltransferases Found in Medicinal Plants That Make Biologically Active Monoterpenoid Indole Alkaloids","year":2016,"lang":"en","type":"article","venue":"PLANT PHYSIOLOGY","topic":"Traditional and Medicinal Uses of Annonaceae","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"","keywords":"Catharanthus roseus; Apocynaceae; Biology; Methyltransferase; Vindoline; O-methyltransferase; Secondary metabolite; Biochemistry; Gene family; Botany; Tocopherol; Indole alkaloid; Gene; Indole test; Genetics; Gene expression; Vitamin E; Methylation; Vinblastine; Antioxidant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006620817,0.0004022499,0.0002396106,0.0001920963,0.0001311123,0.0002540895,0.0001560679,0.0001673561,0.000421827],"category_scores_gemma":[0.0001060103,0.0001250093,0.000346163,0.0001619839,0.0001052042,0.0001656395,0.0001485876,0.0002597735,0.0002642497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002379606,"about_ca_system_score_gemma":0.0001229473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009646992,"about_ca_topic_score_gemma":0.001231581,"domain_scores_codex":[0.9999431,0.000004324458,0.000004298673,0.00002570776,0.00001469418,0.000007867283],"domain_scores_gemma":[0.9999381,0.000009771018,0.00001928316,0.00001043215,0.000008926155,0.00001337005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002402102,0.000004839674,0.000568893,0.00001866454,0.000004526694,0.00002841335,0.000006856073,0.00003465308,0.9975753,0.00001604109,0.000009281966,0.001708436],"study_design_scores_gemma":[0.000007638255,0.0001698257,0.0304975,0.00000691164,0.00005213666,0.0008823151,0.00002719684,0.001844181,0.9608176,0.00003607329,0.005650307,0.000008283977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773797,0.001553526,0.01792131,0.00006729769,0.00001834306,0.000066819,0.001020881,0.0003567218,0.001615473],"genre_scores_gemma":[0.9706975,0.001176714,0.0189819,0.00006687654,0.00001193017,0.00004477888,0.004731259,0.00005438532,0.004234603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009646992,"threshold_uncertainty_score":0.001918197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220932974302598,"score_gpt":0.2510838522021892,"score_spread":0.2288745224591632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}