{"id":"W2263227366","doi":"10.1002/asia.201501253","title":"<i>O</i><sup>6</sup>‐Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross‐Linked DNA is Influenced by the Internucleotide Linkage","year":2015,"lang":"en","type":"article","venue":"Chemistry - An Asian Journal","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phosphodiester bond; Chemistry; DNA; Oligonucleotide; Circular dichroism; Stereochemistry; Deoxyguanosine; Adduct; DNA ligase; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007078981,0.0005920279,0.000422557,0.00002430161,0.0003689011,0.0003553771,0.001127083,0.000564159,0.0003900815],"category_scores_gemma":[0.0002355687,0.0004870519,0.0004442609,0.0001595518,0.0005942842,0.00006638221,0.0001705524,0.001127277,0.00001933071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009849508,"about_ca_system_score_gemma":0.0004996464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001027519,"about_ca_topic_score_gemma":0.000001630302,"domain_scores_codex":[0.997151,0.000112499,0.0006439657,0.0007841422,0.0005389355,0.0007694808],"domain_scores_gemma":[0.9973383,0.00001277554,0.000271663,0.001010828,0.0003174449,0.001048997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005444227,0.0002429428,0.001103129,0.00006437625,0.0002241611,0.00008635898,0.0008458681,0.00003687016,0.9641889,3.956686e-7,0.0270687,0.005593824],"study_design_scores_gemma":[0.002654283,0.0002768828,0.0003630631,0.00006344562,0.00008484774,0.001387669,0.00118743,0.0003007524,0.955254,0.00005292958,0.03777388,0.0006008652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99176,0.0004493194,0.0005275027,0.001056288,0.000147626,0.000148871,0.0002073626,0.00008570661,0.005617281],"genre_scores_gemma":[0.9947615,0.0001370223,0.0003025251,0.0007996677,0.001435193,0.00001368554,0.0002012435,0.00008958701,0.002259553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01070519,"threshold_uncertainty_score":0.9997581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140497416432697,"score_gpt":0.2615109441604955,"score_spread":0.2501059699961686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}