{"id":"W2263864814","doi":"10.1158/1078-0432.ccr-15-2631","title":"Mutations in TSC1, TSC2, and MTOR Are Associated with Response to Rapalogs in Patients with Metastatic Renal Cell Carcinoma","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"Baker Hughes (Canada); University Hospital Foundation","funders":"National Cancer Institute","keywords":"TSC1; PI3K/AKT/mTOR pathway; TSC2; Medicine; Cancer; Cancer research; Oncology; Internal medicine; Renal cell carcinoma; Sirolimus; Biology; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002676696,0.0001927711,0.000563789,0.0005157784,0.00006618861,0.00002286545,0.0001289549,0.0001002502,0.0001097845],"category_scores_gemma":[0.002125191,0.0001074163,0.00004835896,0.0009814914,0.0003952121,0.00008360338,0.00009187741,0.0005369278,0.0000298777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008378022,"about_ca_system_score_gemma":0.0008324985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005076406,"about_ca_topic_score_gemma":0.002692131,"domain_scores_codex":[0.9958636,0.001362981,0.0005603309,0.000651039,0.0009395152,0.0006225898],"domain_scores_gemma":[0.9952091,0.003232233,0.0001113113,0.0004088104,0.0005446638,0.0004938742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02524973,0.0009390425,0.9702409,0.00003595972,0.00004952335,0.0004965371,0.0002804055,0.000005797532,0.0004658109,0.000002016844,0.0003113357,0.001922921],"study_design_scores_gemma":[0.01904489,0.006700673,0.9721551,0.0006675386,0.00005210677,0.000001930802,0.0001549161,0.000007014007,0.0009143985,0.00002486201,0.0001318114,0.0001447434],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948081,0.000188063,0.000008030824,0.003204789,0.00002633684,0.001519282,0.00007337772,0.00001401438,0.0001580291],"genre_scores_gemma":[0.9978871,0.00001995842,0.0002082084,0.0001647172,0.00003107036,0.000399548,0.00001715053,0.00004081142,0.001231408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006204843,"threshold_uncertainty_score":0.438031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1292294006372624,"score_gpt":0.4265416049270228,"score_spread":0.2973122042897604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}