{"id":"W2263967500","doi":"10.82308/18060","title":"Synthesis, physicochemical and biochemical properties of C3'-modified 2',5'-linked oligonucleotides","year":2003,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Oligonucleotide; RNA; DNA; Furanose; Chemistry; Nucleic acid; Biochemistry; Stereochemistry; Combinatorial chemistry; Ring (chemistry); Gene; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001951009,0.0003070307,0.0001705285,0.0001121202,0.0001173766,0.0001855653,0.0001235204,0.000266545,0.0006786246],"category_scores_gemma":[0.0002877059,0.0001573201,0.0001699152,0.0001484459,0.0001337785,0.0001229551,0.00006996745,0.0002555207,0.0002648429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001916196,"about_ca_system_score_gemma":0.0001595925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004740639,"about_ca_topic_score_gemma":0.0005679795,"domain_scores_codex":[0.9998926,0.00001917625,0.000009344599,0.00003267844,0.00002901833,0.00001729914],"domain_scores_gemma":[0.9998391,0.00004251098,0.00003726823,0.00001111262,0.00004055781,0.0000294495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001582868,0.00000421173,0.00003810772,0.00001508361,0.000001229882,0.00001140054,0.00000841347,0.00008552539,0.9992003,0.00003148942,0.000007455208,0.0005810598],"study_design_scores_gemma":[0.000003380583,0.0001251169,0.001098377,0.000002565046,0.000005357223,0.00004452314,0.000007847514,0.0003604318,0.9969751,0.00002133898,0.001349718,0.000006337988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859969,0.001879044,0.009749749,0.00005791822,0.00003602526,0.00006274744,0.0004447188,0.00005671306,0.001716174],"genre_scores_gemma":[0.9770781,0.001307327,0.0166464,0.00008928277,0.00001750518,0.0001067366,0.001010753,0.00003667216,0.003707171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006786246,"threshold_uncertainty_score":0.002270222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226855055352873,"score_gpt":0.2207725154889472,"score_spread":0.2085039649354185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}