{"id":"W2263985431","doi":"10.1186/s12888-016-0708-x","title":"Is adjunctive pharmacotherapy in attention-deficit/hyperactivity disorder cost-effective in Canada: a cost-effectiveness assessment of guanfacine extended-release as an adjunctive therapy to a long-acting stimulant for the treatment of ADHD","year":2016,"lang":"en","type":"article","venue":"BMC Psychiatry","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Stimulant; Methylphenidate; Attention deficit hyperactivity disorder; Guanfacine; Medicine; Psychiatry; Pharmacotherapy; Adjunctive treatment; Amphetamine; Dopamine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002537583,0.0008146088,0.00156857,0.001526498,0.0008686238,0.002042517,0.001576492,0.001171564,0.003272804],"category_scores_gemma":[0.01375618,0.0004117623,0.002549094,0.002380396,0.0008102946,0.0007395913,0.001141473,0.001245485,0.00007654288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.07805964,"about_ca_system_score_gemma":0.08569825,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9536702,"about_ca_topic_score_gemma":0.9516738,"domain_scores_codex":[0.9974906,0.001001131,0.0001153396,0.0001832454,0.000685057,0.0005246016],"domain_scores_gemma":[0.9954217,0.001968191,0.0007220602,0.00008363317,0.0009984433,0.0008058921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.05062497,0.003917928,0.2789852,0.007155834,0.01080453,0.001128927,0.000480926,0.3534261,0.002320367,0.01063332,0.01337664,0.2671452],"study_design_scores_gemma":[0.01090126,0.009876476,0.3476886,0.002342236,0.01448046,0.0007386997,0.001696391,0.5958752,0.001534275,0.003626021,0.01096295,0.0002774546],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9491763,0.01982618,0.00315492,0.006506183,0.0001882011,0.00251351,0.008089215,0.0001161184,0.0104294],"genre_scores_gemma":[0.9900502,0.004635576,0.002659025,0.0004186301,0.00003337917,0.0001749582,0.001428382,0.00001005986,0.0005898256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07805964,"threshold_uncertainty_score":0.5663649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06967315618206245,"score_gpt":0.4095559126088418,"score_spread":0.3398827564267794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}