{"id":"W2263985431","doi":"10.1186/s12888-016-0708-x","title":"Is adjunctive pharmacotherapy in attention-deficit/hyperactivity disorder cost-effective in Canada: a cost-effectiveness assessment of guanfacine extended-release as an adjunctive therapy to a long-acting stimulant for the treatment of ADHD","year":2016,"lang":"en","type":"article","venue":"BMC Psychiatry","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Stimulant; Methylphenidate; Attention deficit hyperactivity disorder; Guanfacine; Medicine; Psychiatry; Pharmacotherapy; Adjunctive treatment; Amphetamine; Dopamine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006158648,0.0005774595,0.001190646,0.0003962169,0.0001237745,0.00001292567,0.0001974639,0.0001352826,0.0002047575],"category_scores_gemma":[0.0001601016,0.0003664925,0.0003703788,0.0007428481,0.0001048203,0.00032647,0.00002938742,0.0002438911,0.000003160759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001959792,"about_ca_system_score_gemma":0.002603272,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.2282992,"about_ca_topic_score_gemma":0.4371448,"domain_scores_codex":[0.9964149,0.000678089,0.0007676111,0.0009258835,0.0006168901,0.0005966203],"domain_scores_gemma":[0.9962091,0.001895297,0.0005191242,0.0007194303,0.0004450346,0.0002119929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01130303,0.0068393,0.8528478,0.0001450841,0.0005226409,0.000004825025,0.0004030584,0.0009619988,0.01007826,0.00005903544,0.00001005765,0.1168249],"study_design_scores_gemma":[0.03235364,0.004484299,0.954266,0.0005388707,0.0002126559,0.00001541376,0.004175393,0.00245097,0.000849093,0.00006631447,0.0001945964,0.0003927705],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600476,0.0008131116,0.01966332,0.001103964,0.0006675863,0.0171628,0.0004767676,0.00002640228,0.0000384542],"genre_scores_gemma":[0.9920548,0.0003542505,0.0005482285,0.0002284204,0.0001165506,0.006514256,0.00004335145,0.00009240981,0.00004768279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2088456,"threshold_uncertainty_score":0.9998787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06967315618206245,"score_gpt":0.4095559126088418,"score_spread":0.3398827564267794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}