{"id":"W2264278974","doi":"10.3899/jrheum.141580","title":"Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy","year":2015,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"CYTED Ciencia y Tecnología para el Desarrollo; Janssen Scientific Affairs","keywords":"Medicine; Placebo; Rheumatoid arthritis; Internal medicine; Clinical endpoint; Pharmacokinetics; Pharmacodynamics; Gastroenterology; Arthritis; Rheumatoid factor; Methotrexate; Randomized controlled trial; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001366403,0.0004132248,0.001312875,0.0003506492,0.0001700713,0.00002279668,0.0008224024,0.0001940363,0.00006213477],"category_scores_gemma":[0.0003045813,0.000274048,0.0001125936,0.0003106394,0.0005466299,0.0005469603,0.0001512479,0.0008569325,0.00002082879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00013324,"about_ca_system_score_gemma":0.0003258665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003368139,"about_ca_topic_score_gemma":0.001284634,"domain_scores_codex":[0.994796,0.002343785,0.001719549,0.0003494026,0.000248126,0.0005431743],"domain_scores_gemma":[0.9960542,0.0007122752,0.001920571,0.0007287929,0.0004727131,0.0001114065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1595234,0.01511177,0.7088934,0.00003553055,0.002093576,0.00006417491,0.07918008,0.0008714565,0.001741441,0.00005671536,0.001640849,0.03078759],"study_design_scores_gemma":[0.5164398,0.03211591,0.3731275,0.003949571,0.0003836648,0.001015538,0.06383092,0.0001989238,0.003441139,0.002279462,0.001308035,0.001909532],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908644,0.006920793,0.00008329876,0.0001421974,0.001084507,0.0007798276,0.00008887057,0.00002372274,0.00001238205],"genre_scores_gemma":[0.9964985,0.003102028,0.0001805968,0.00004484393,0.00000617877,0.00001721927,0.00009079608,0.00004982777,0.000009992717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3569164,"threshold_uncertainty_score":0.9999712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0217230574906601,"score_gpt":0.2682663673139844,"score_spread":0.2465433098233243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}