{"id":"W2264278974","doi":"10.3899/jrheum.141580","title":"Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy","year":2015,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"CYTED Ciencia y Tecnología para el Desarrollo; Janssen Scientific Affairs","keywords":"Medicine; Placebo; Rheumatoid arthritis; Internal medicine; Clinical endpoint; Pharmacokinetics; Pharmacodynamics; Gastroenterology; Arthritis; Rheumatoid factor; Methotrexate; Randomized controlled trial; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005757167,0.00158444,0.003141832,0.0004509449,0.0007690877,0.00101185,0.0008584702,0.001436424,0.002964459],"category_scores_gemma":[0.002904038,0.0007631338,0.002137923,0.0005039729,0.001255781,0.0007692802,0.000408488,0.0023452,0.0007235032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005768181,"about_ca_system_score_gemma":0.002024349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007719506,"about_ca_topic_score_gemma":0.001209743,"domain_scores_codex":[0.9982035,0.001011753,0.0001757903,0.0002259186,0.0002089069,0.0001741301],"domain_scores_gemma":[0.9976715,0.0004842396,0.0004483311,0.0002998123,0.0002868895,0.0008091383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9277501,0.02739691,0.003371078,0.00052167,0.002063195,0.00008673142,0.0001234152,0.0004826141,0.01346503,0.00005228512,0.001022969,0.0236641],"study_design_scores_gemma":[0.788472,0.1966838,0.01185357,0.00002368659,0.001063372,0.0000845593,0.00002618069,0.0001643226,0.0008132575,0.00003630637,0.0007601709,0.00001884761],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893127,0.003162621,0.0008429482,0.0003191208,0.0002472306,0.003762138,0.0009236558,0.00008600953,0.001343583],"genre_scores_gemma":[0.985689,0.002564542,0.002243662,0.001168379,0.0003959119,0.003721819,0.002644597,0.00004032517,0.001531745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005757167,"threshold_uncertainty_score":0.03044719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0217230574906601,"score_gpt":0.2682663673139844,"score_spread":0.2465433098233243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}