{"id":"W2266142448","doi":"10.1182/blood.v124.21.396.396","title":"The Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330) Demonstrates Broad and Durable Clinical Activity in Relapsed / Refractory Non Hodgkin’s Lymphoma (NHL)","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ozmosis Research (Canada); Alberta Health Services; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Neutropenia; Lymphoma; Nausea; Nuclear export signal; Medicine; Anemia; Internal medicine; Cancer research; Vomiting; Progressive disease; Cell cycle checkpoint; Gastroenterology; Cancer; Cell cycle; Oncology; Chemotherapy; Cell nucleus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002009451,0.0003006416,0.000452514,0.0001547466,0.0001105477,0.0001996195,0.0002120149,0.0001885708,0.001779831],"category_scores_gemma":[0.0001482068,0.000133427,0.0001485497,0.0001331131,0.000242389,0.0002063088,0.0001199529,0.0006102168,0.0002963298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001568507,"about_ca_system_score_gemma":0.0002012467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003039797,"about_ca_topic_score_gemma":0.001100335,"domain_scores_codex":[0.9999453,0.00001675712,0.000004515114,0.00000752739,0.000009166141,0.00001675613],"domain_scores_gemma":[0.999908,0.00002207434,0.00002268434,0.000008570394,0.000004995854,0.00003372001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.05106807,0.01684606,0.0151425,0.0008883373,0.0003828438,0.0004869207,0.0003520994,0.002355804,0.5945443,0.0002664072,0.002414037,0.3152526],"study_design_scores_gemma":[0.05324791,0.6085285,0.1241823,0.0001091485,0.0005236496,0.00247982,0.0002507107,0.00325254,0.1963259,0.0001712975,0.01088421,0.00004412179],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987343,0.0005359208,0.0001465686,0.00003173173,0.0000048987,0.00004636743,0.00008172813,0.00003673752,0.000381725],"genre_scores_gemma":[0.9979817,0.0007000384,0.0002788334,0.00004690417,0.00001445303,0.00004943646,0.0002661025,0.000006117921,0.0006565881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001779831,"threshold_uncertainty_score":0.005954087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007075050263865582,"score_gpt":0.2392911379085903,"score_spread":0.2322160876447247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}