{"id":"W2266142448","doi":"10.1182/blood.v124.21.396.396","title":"The Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330) Demonstrates Broad and Durable Clinical Activity in Relapsed / Refractory Non Hodgkin’s Lymphoma (NHL)","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ozmosis Research (Canada); Alberta Health Services; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Neutropenia; Lymphoma; Nausea; Nuclear export signal; Medicine; Anemia; Internal medicine; Cancer research; Vomiting; Progressive disease; Cell cycle checkpoint; Gastroenterology; Cancer; Cell cycle; Oncology; Chemotherapy; Cell nucleus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004546498,0.0001428083,0.0002098538,0.00002835965,0.0001011968,0.0000210385,0.0001025721,0.000259788,0.000003578879],"category_scores_gemma":[0.0002100741,0.0001091852,0.00007342833,0.00008691227,0.0001582175,0.000008173857,0.00006631109,0.0001488136,0.000003011301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008733979,"about_ca_system_score_gemma":0.00006910574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006352209,"about_ca_topic_score_gemma":0.000145121,"domain_scores_codex":[0.9989357,0.000157368,0.0002847099,0.0003273394,0.00009956978,0.0001953255],"domain_scores_gemma":[0.9993667,0.00005617243,0.0001620443,0.000272748,0.00007891646,0.00006340731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000965533,0.0005118424,0.05012383,0.00002406922,0.000119994,0.000003374164,0.00006977592,0.000002801985,0.9149039,0.00003610117,0.001473839,0.03176494],"study_design_scores_gemma":[0.006390341,0.002888993,0.6540044,0.00003980767,0.0001206478,0.00005453062,0.0001812506,0.0003455274,0.3074363,0.0001691084,0.02799098,0.0003781659],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99866,0.0001457567,0.00002171578,0.00007949085,0.000181916,0.0001407642,0.000004552094,0.00001127303,0.00075453],"genre_scores_gemma":[0.9989762,0.0002074378,0.0003384197,0.00008673804,0.0002636381,0.000004667755,0.000008203637,0.00002435503,0.00009031986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6074677,"threshold_uncertainty_score":0.4452442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007075050263865582,"score_gpt":0.2392911379085903,"score_spread":0.2322160876447247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}