{"id":"W2266189321","doi":"10.1152/ajplung.00157.2015","title":"Thrombin stimulates albumin transcytosis in lung microvascular endothelial cells via activation of acid sphingomyelinase","year":2016,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Blood properties and coagulation","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Transcytosis; Albumin; Transcellular; Sphingomyelin; Thrombin; Cell biology; Acid sphingomyelinase; Endothelial stem cell; Biology; Paracellular transport; Endothelium; Biochemistry; Chemistry; Endocytosis; Immunology; Platelet; Endocrinology; Cell; In vitro; Cholesterol; Permeability (electromagnetism); Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000241524,0.0002641264,0.0009779969,0.0002385187,0.00004145377,0.000004195215,0.0001492241,0.000130275,0.00004473451],"category_scores_gemma":[0.00003669493,0.000179776,0.0003364445,0.0002234193,0.0005047342,0.0001163756,0.00004650706,0.0002447303,0.0000017817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005238329,"about_ca_system_score_gemma":0.00009370498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001302792,"about_ca_topic_score_gemma":0.000001314152,"domain_scores_codex":[0.9981595,0.0003158048,0.0006725018,0.0003379848,0.0001788964,0.0003353507],"domain_scores_gemma":[0.9987596,0.00008595597,0.0005556767,0.0002884027,0.0001890821,0.0001213275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001343773,0.0002546684,0.0003727706,0.0001321335,0.0003865704,0.00001593421,0.0003254866,0.000172907,0.9907238,0.00002876304,0.00001852239,0.00622463],"study_design_scores_gemma":[0.003145646,0.001744314,0.0132915,0.0002518316,0.0002852383,0.00005051729,0.0001297884,0.0005552355,0.9799543,0.0003407289,0.00005828734,0.0001926073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928448,0.001149398,0.005208875,0.0004244139,0.00009775526,0.0002505285,0.000005988857,0.000009269059,0.000008996745],"genre_scores_gemma":[0.9982209,0.000437486,0.0008743465,0.0002853646,0.0001209826,0.000005973794,0.000011607,0.00003530272,0.000008068623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01291873,"threshold_uncertainty_score":0.7331051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004698952260862253,"score_gpt":0.2180766049755402,"score_spread":0.213377652714678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}