{"id":"W2266189321","doi":"10.1152/ajplung.00157.2015","title":"Thrombin stimulates albumin transcytosis in lung microvascular endothelial cells via activation of acid sphingomyelinase","year":2016,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Blood properties and coagulation","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Transcytosis; Albumin; Transcellular; Sphingomyelin; Thrombin; Cell biology; Acid sphingomyelinase; Endothelial stem cell; Biology; Paracellular transport; Endothelium; Biochemistry; Chemistry; Endocytosis; Immunology; Platelet; Endocrinology; Cell; In vitro; Cholesterol; Permeability (electromagnetism); Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001754733,0.0002766238,0.0002459841,0.0001507631,0.0001198019,0.0002502321,0.0001149422,0.0002706974,0.0007500938],"category_scores_gemma":[0.0001690861,0.0001072368,0.0003633796,0.0001442934,0.000132049,0.0002228507,0.0002348766,0.0004735509,0.000192748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002663816,"about_ca_system_score_gemma":0.0001122656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001233216,"about_ca_topic_score_gemma":0.001002034,"domain_scores_codex":[0.999798,0.00005367694,0.00002107089,0.00002872665,0.00005102641,0.0000475127],"domain_scores_gemma":[0.9999143,0.00003138649,0.00001721522,0.000009166101,0.00001081801,0.00001711644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001039801,0.00001329139,0.00009335299,0.00002578617,0.000003718504,0.00005842811,0.00001121776,0.00001964292,0.9989493,0.00003884501,0.0000190032,0.0006634042],"study_design_scores_gemma":[0.00004392165,0.0005099201,0.008979953,0.000005609926,0.00001954062,0.0003623151,0.00002935447,0.002008235,0.9870007,0.00007699813,0.0009577478,0.00000573322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993009,0.0024162,0.003108248,0.0001817947,0.00003569425,0.00002885744,0.000180341,0.0000621591,0.0009776676],"genre_scores_gemma":[0.9959378,0.0007402377,0.002283299,0.00007668498,0.00001625306,0.00002884295,0.0001785094,0.000007384776,0.0007309804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001233216,"threshold_uncertainty_score":0.002509296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004698952260862253,"score_gpt":0.2180766049755402,"score_spread":0.213377652714678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}