{"id":"W2266228206","doi":"10.1038/tpj.2015.65","title":"A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease","year":2015,"lang":"en","type":"review","venue":"The Pharmacogenomics Journal","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital","funders":"National Institute of Environmental Health Sciences; National Institute for Health and Care Research; National Institute of Nursing Research; Medical Research Council; National Institutes of Health; Pfizer; National Heart, Lung, and Blood Institute; Sunovion; AstraZeneca; CSL Behring; GlaxoSmithKline; COPD Foundation","keywords":"COPD; Single-nucleotide polymorphism; Genome-wide association study; Medicine; Genetic association; Internal medicine; Bioinformatics; Genetics; Gene; Genotype; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00183789,0.0005045461,0.002041274,0.001008239,0.0002178791,0.00004360798,0.0009847482,0.0001224409,0.0001719001],"category_scores_gemma":[0.0003357739,0.000265925,0.001891796,0.002080344,0.0002494879,0.00005782359,0.0003670381,0.001155528,0.00003739945],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002529854,"about_ca_system_score_gemma":0.006739802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004743811,"about_ca_topic_score_gemma":0.000004963228,"domain_scores_codex":[0.9956824,0.001631234,0.001219824,0.0003837545,0.0005997327,0.0004831222],"domain_scores_gemma":[0.9967335,0.0003739537,0.0009486453,0.0007996631,0.0002492661,0.0008949847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01154015,0.0008267767,0.002344922,0.005527776,0.0124032,0.006246348,0.001175055,0.004980412,0.00110991,0.000007595379,0.0005309567,0.9533069],"study_design_scores_gemma":[0.0007676854,0.00007378768,0.01466641,0.001802878,0.02818792,0.0007016141,0.00007401723,0.0001483954,0.000005852367,0.00003019192,0.9532003,0.0003409465],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07779507,0.9196896,0.00001316819,0.0003577321,0.0002765946,0.00131674,0.0004657758,0.000009875036,0.0000754736],"genre_scores_gemma":[0.03285294,0.9653749,0.00001475039,0.00038848,0.0007134395,0.00007550187,0.00004443193,0.00009344382,0.0004420328],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.952966,"threshold_uncertainty_score":0.9999793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04634823105468396,"score_gpt":0.3639953707109019,"score_spread":0.317647139656218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}