{"id":"W2266524926","doi":"10.1016/j.ebiom.2016.02.015","title":"The BuMPy Road to COPD Gene Discovery","year":2016,"lang":"en","type":"letter","venue":"EBioMedicine","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"","keywords":"COPD; Medicine; Genome-wide association study; Genetics; Population; Imputation (statistics); Pulmonary disease; Bioinformatics; Gene; Biology; Internal medicine; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006163068,0.000757348,0.001111144,0.0005726212,0.0003413661,0.0000990352,0.0009043654,0.0006658071,0.001276228],"category_scores_gemma":[0.0004563006,0.0004041732,0.0003861365,0.0007218745,0.001117519,0.0001432614,0.0005128147,0.002022808,0.001942054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0013109,"about_ca_system_score_gemma":0.001021236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001906629,"about_ca_topic_score_gemma":0.000009477514,"domain_scores_codex":[0.9937676,0.0001922416,0.0007734753,0.001209905,0.002374813,0.001682003],"domain_scores_gemma":[0.9959069,0.0005318528,0.0002200327,0.002280288,0.0003849706,0.0006759519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003641449,0.00004661045,0.0002962256,0.0004921554,0.0003767977,0.00385399,0.00005285556,6.795096e-8,0.002719854,0.00002029132,0.9323087,0.05946836],"study_design_scores_gemma":[0.002442348,0.0003979552,0.01135869,0.00115746,0.0002937232,0.0003504153,0.00005695896,0.000008641412,0.0003728763,0.0001784941,0.9829236,0.0004588103],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003209587,0.008150574,0.0002222058,0.9746119,0.002578523,0.002257773,0.000603415,0.0001536782,0.008212289],"genre_scores_gemma":[0.002801252,0.0011206,0.0001202984,0.6310756,0.05180581,0.0003871009,0.001506462,0.0003090311,0.3108738],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3435363,"threshold_uncertainty_score":0.999841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705063741196717,"score_gpt":0.3008322981830278,"score_spread":0.2837816607710607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}