{"id":"W2266573952","doi":"10.1038/ng.3383","title":"Genetic association analyses highlight biological pathways underlying mitral valve prolapse","year":2015,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":135,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Genome Canada; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute; Fonds de Recherche du Québec - Santé; American Heart Association; Canadian Institutes of Health Research; Agence Nationale de la Recherche; Fondation Leducq; European Commission; National Institutes of Health; Sociedad Española de Cardiología; Massachusetts General Hospital; National Institute of General Medical Sciences","keywords":"Biology; Mitral valve prolapse; Zebrafish; Tensin; Genome-wide association study; Candidate gene; Genetics; Genetic association; Phenotype; Internal medicine; Mitral valve; Gene; Bioinformatics; Single-nucleotide polymorphism; Medicine; PTEN; Signal transduction; Genotype; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001318895,0.001074361,0.0004833549,0.002097167,0.000578798,0.001428221,0.0007447753,0.001162383,0.004039862],"category_scores_gemma":[0.004709166,0.0004399455,0.001549316,0.001636794,0.0008404976,0.0006362737,0.0008208354,0.001375118,0.0002842918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002714482,"about_ca_system_score_gemma":0.0004890402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00180466,"about_ca_topic_score_gemma":0.002308366,"domain_scores_codex":[0.9986865,0.000443091,0.0001237447,0.0004090701,0.0002178718,0.0001197723],"domain_scores_gemma":[0.9962245,0.002436392,0.0007912356,0.0002063508,0.0001438681,0.0001976153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003356631,0.0003323953,0.7671385,0.0004972828,0.006022214,0.01359303,0.00077099,0.003470057,0.1257796,0.01354342,0.00347034,0.06202553],"study_design_scores_gemma":[0.0003122255,0.0003517255,0.9322929,0.0002287255,0.004097049,0.01033093,0.0005807749,0.006357688,0.01235827,0.02508075,0.007899675,0.0001092237],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712612,0.006278023,0.01000443,0.005518821,0.0003483948,0.00002573833,0.001638692,0.000142537,0.004782077],"genre_scores_gemma":[0.9921421,0.001925531,0.003844146,0.0005342553,0.0002599981,0.00001163193,0.0004015472,0.00004574954,0.0008350005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004039862,"threshold_uncertainty_score":0.01351464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09273949089582924,"score_gpt":0.3972723467989947,"score_spread":0.3045328559031655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}