{"id":"W2266613162","doi":"10.1038/ncomms10160","title":"A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; University of Alberta","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; American Heart Association","keywords":"Phenotype; Biology; Phenotypic switching; Von Willebrand factor; Genetics; Cell biology; Gene; Endothelial stem cell; Immunology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001951232,0.0001016864,0.0001408976,0.0001927068,0.0001343849,0.0003347662,0.0002345201,0.0001549445,0.0003877233],"category_scores_gemma":[0.0004454428,0.000126897,0.0001133837,0.00008470113,0.000309463,0.0002482751,0.0003130689,0.0002553753,0.00007893357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002632674,"about_ca_system_score_gemma":0.0001413287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002062981,"about_ca_topic_score_gemma":0.0003588723,"domain_scores_codex":[0.9998503,0.00002365909,0.000008222546,0.00004540733,0.00004737483,0.00002505207],"domain_scores_gemma":[0.9997687,0.0000770213,0.00006017918,0.00003994037,0.00001667308,0.00003745165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003178125,0.000007794647,0.001460866,0.000008093148,0.000004026105,0.00006860581,0.0000223489,0.0009849641,0.9930929,0.001963343,0.00001393463,0.002341432],"study_design_scores_gemma":[0.00002137219,0.0001989274,0.0372444,0.000007632658,0.00002939391,0.0009044151,0.00009692404,0.08237319,0.8715819,0.005565609,0.00194393,0.00003225791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709541,0.000128958,0.02782143,0.00004412137,0.000006018446,0.000008782044,0.000037997,0.00009651239,0.0009021374],"genre_scores_gemma":[0.9976614,0.00004093226,0.002060176,0.00001123235,0.000002215357,0.000006471972,0.00002131981,0.00001204097,0.000184178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003877233,"threshold_uncertainty_score":0.00191021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008514241025443674,"score_gpt":0.2549124537898679,"score_spread":0.2463982127644243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}