{"id":"W2266613162","doi":"10.1038/ncomms10160","title":"A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; University of Alberta","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; American Heart Association","keywords":"Phenotype; Biology; Phenotypic switching; Von Willebrand factor; Genetics; Cell biology; Gene; Endothelial stem cell; Immunology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001864038,0.0001053684,0.0001360746,0.00006281263,0.00008041347,0.000006627615,0.0005930996,0.000204008,0.000005031869],"category_scores_gemma":[0.00008927016,0.00008613951,0.00008913966,0.0001505183,0.00005174098,0.000003803305,0.0003040953,0.0001809252,0.000003460717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002236258,"about_ca_system_score_gemma":0.0000602814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001830731,"about_ca_topic_score_gemma":0.001292046,"domain_scores_codex":[0.9991838,0.0001451108,0.0002325867,0.0001935857,0.00009283753,0.0001520295],"domain_scores_gemma":[0.9984324,0.00004898229,0.0001265507,0.001269517,0.00008265189,0.00003992502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001012671,0.00005991243,0.00368212,0.000002573442,0.00002678393,6.242976e-8,0.00003570147,0.0009723429,0.9915798,0.0001381619,0.00004708616,0.003445317],"study_design_scores_gemma":[0.001641962,0.000140397,0.009120757,0.00008558486,0.000128263,0.000007200577,0.0001528653,0.01683161,0.9614363,0.000447448,0.009424542,0.0005831207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844338,0.01111789,0.003907066,0.0001498653,0.00003374329,0.0001148678,0.00002911089,0.000008675972,0.0002049505],"genre_scores_gemma":[0.9942015,0.0001710594,0.005373979,0.00005577257,0.00007525563,0.00001917297,0.00005063196,0.00001667431,0.00003591015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03014356,"threshold_uncertainty_score":0.3512667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008514241025443674,"score_gpt":0.2549124537898679,"score_spread":0.2463982127644243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}