{"id":"W2266633395","doi":"10.1038/nchembio.2018","title":"Assembly and clustering of natural antibiotics guides target identification","year":2016,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Antibiotics; Computational biology; Mode of action; Streptomyces; Biology; Limiting; Microbiology; Bacteria; Genetics; Biochemistry; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001413458,0.0001068998,0.0002487627,0.00005306905,0.00001775813,0.000004250651,0.00008310279,0.0004393446,0.00002957402],"category_scores_gemma":[0.0009536507,0.00005647026,0.00005092785,0.00008986975,0.0001805785,0.0000356748,0.00007353213,0.0002397029,0.000004343512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002252838,"about_ca_system_score_gemma":0.00001552455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002907374,"about_ca_topic_score_gemma":7.337296e-7,"domain_scores_codex":[0.999248,0.0000193747,0.0002379133,0.0002771517,0.00005905755,0.0001584949],"domain_scores_gemma":[0.9994324,0.0001068763,0.0000963229,0.0001711643,0.0001432772,0.00004997187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001023402,0.00002267821,0.001592414,0.00006227165,0.00002838667,0.000001294394,0.0000062907,4.636776e-9,0.9838456,0.0002668098,0.001000033,0.0130719],"study_design_scores_gemma":[0.0003391988,0.00004046755,0.002903312,0.00007440225,0.00002778708,0.00004461524,0.000003513429,0.00001457652,0.9912583,0.0002199436,0.00499162,0.00008231096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906603,0.002453025,0.0000852592,0.006175451,0.0003051852,0.0001261883,0.00002565556,0.00002881815,0.0001401396],"genre_scores_gemma":[0.9957364,0.0001926232,0.003258932,0.0003330623,0.0002196767,6.400496e-8,0.00002856986,0.000007963485,0.0002226908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01298959,"threshold_uncertainty_score":0.3388628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008795043677404496,"score_gpt":0.2727207900314841,"score_spread":0.2639257463540796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}