{"id":"W2266633395","doi":"10.1038/nchembio.2018","title":"Assembly and clustering of natural antibiotics guides target identification","year":2016,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Antibiotics; Computational biology; Mode of action; Streptomyces; Biology; Limiting; Microbiology; Bacteria; Genetics; Biochemistry; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004618092,0.0005048626,0.0008503254,0.0009507287,0.000946317,0.001958136,0.0006604213,0.0006876526,0.002502675],"category_scores_gemma":[0.001744377,0.0008330981,0.0006636103,0.0006762578,0.0007010851,0.0008497264,0.001119501,0.001298641,0.00332362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001263121,"about_ca_system_score_gemma":0.001308302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001508151,"about_ca_topic_score_gemma":0.004610457,"domain_scores_codex":[0.9990914,0.000140615,0.00006260769,0.0002808958,0.000303376,0.0001210595],"domain_scores_gemma":[0.9987032,0.0002534602,0.0002344591,0.0002680453,0.0003462334,0.000194622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002529775,0.0000961646,0.002206101,0.0001315234,0.00002694544,0.0001129255,0.0001325,0.002891263,0.9635299,0.002203123,0.001670891,0.02674565],"study_design_scores_gemma":[0.00002572484,0.000262471,0.008309184,0.00004314325,0.00004014692,0.0002442745,0.000246556,0.03184873,0.9321371,0.002356695,0.02443997,0.00004589475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7441418,0.004129038,0.2271919,0.001038227,0.0003763296,0.0003651207,0.001363401,0.004482502,0.01691187],"genre_scores_gemma":[0.8159528,0.001571239,0.1658825,0.0005107789,0.0001028822,0.0002107178,0.003033253,0.00100958,0.01172632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002502675,"threshold_uncertainty_score":0.009164691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008795043677404496,"score_gpt":0.2727207900314841,"score_spread":0.2639257463540796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}