{"id":"W2266646185","doi":"10.1095/biolreprod.115.137646","title":"Absence of Peroxiredoxin 6 Amplifies the Effect of Oxidant Stress on Mobility and SCSA/CMA3 Defined Chromatin Quality and Impairs Fertilizing Ability of Mouse Spermatozoa1","year":2016,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research","keywords":"Biology; Spermatozoon; Oxidative stress; Sperm; DNA fragmentation; DNA damage; Andrology; Sperm motility; Capacitation; Chromatin; Reactive oxygen species; Motility; Cell biology; Genetics; Endocrinology; DNA; Programmed cell death; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001491477,0.0001144887,0.0004473063,0.00005446055,0.00003313375,0.000001054142,0.00004162974,0.00009252926,0.00001032886],"category_scores_gemma":[0.00323599,0.00005899279,0.00006735046,0.00008556546,0.0009780151,0.00004040987,0.00003569309,0.00006081017,2.97652e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000225754,"about_ca_system_score_gemma":0.00002151102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003330769,"about_ca_topic_score_gemma":0.00001089663,"domain_scores_codex":[0.9986156,0.0003265434,0.0004729416,0.0003745139,0.0001131378,0.00009726288],"domain_scores_gemma":[0.9983546,0.0005138642,0.000355544,0.0005995248,0.0001473608,0.00002906653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006436032,0.00008068467,0.3999673,0.0004640459,0.00002795396,9.697811e-8,0.00008547454,8.915389e-7,0.5910205,0.00007832795,0.000002310262,0.007628834],"study_design_scores_gemma":[0.0004308083,0.0008723809,0.4921214,0.0001009109,0.00002669693,0.00001320771,0.00007188009,0.000006065135,0.5062518,0.00007431043,0.00000260224,0.00002794842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978662,0.001074666,0.00007392134,0.00037539,0.00009204767,0.0004596484,0.00002687909,0.00001769214,0.00001357181],"genre_scores_gemma":[0.9996535,0.0001414596,0.0001464191,0.000002475812,0.00002916928,0.000009670526,0.000005234057,0.000005137415,0.000006937919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09215407,"threshold_uncertainty_score":0.3874016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0234089596450564,"score_gpt":0.2922705167155993,"score_spread":0.2688615570705429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}