{"id":"W2266646185","doi":"10.1095/biolreprod.115.137646","title":"Absence of Peroxiredoxin 6 Amplifies the Effect of Oxidant Stress on Mobility and SCSA/CMA3 Defined Chromatin Quality and Impairs Fertilizing Ability of Mouse Spermatozoa1","year":2016,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research","keywords":"Biology; Spermatozoon; Oxidative stress; Sperm; DNA fragmentation; DNA damage; Andrology; Sperm motility; Capacitation; Chromatin; Reactive oxygen species; Motility; Cell biology; Genetics; Endocrinology; DNA; Programmed cell death; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003744503,0.0005718389,0.0003923555,0.0006904566,0.0002644248,0.0003292917,0.0004173251,0.0005924846,0.003868251],"category_scores_gemma":[0.0001988222,0.000311031,0.000593451,0.000239077,0.0004810269,0.0003106268,0.0004189785,0.0009863728,0.0006284626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002463592,"about_ca_system_score_gemma":0.0002329579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009205,"about_ca_topic_score_gemma":0.00115137,"domain_scores_codex":[0.9996287,0.00004655572,0.00004350766,0.00009689692,0.0001118231,0.0000725815],"domain_scores_gemma":[0.9995494,0.00004329842,0.0001430438,0.00005322527,0.0000429727,0.0001680118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009579827,0.00002157737,0.000242535,0.00003052299,0.000006048196,0.00004078514,0.00001442897,0.00001407992,0.9989386,0.00005131082,0.00003207974,0.0005122484],"study_design_scores_gemma":[0.00001849464,0.0006069229,0.01465324,0.00001488378,0.00002321589,0.0004391301,0.00004665499,0.0004141905,0.9815322,0.00005509431,0.002187704,0.000008317154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886641,0.003964543,0.004220358,0.0002340664,0.0001174905,0.00004065308,0.001292526,0.0002443243,0.001221995],"genre_scores_gemma":[0.9850327,0.0017782,0.00285269,0.0001071529,0.00002560635,0.00006508034,0.001880342,0.00009527997,0.008163049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003868251,"threshold_uncertainty_score":0.01294059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0234089596450564,"score_gpt":0.2922705167155993,"score_spread":0.2688615570705429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}